『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Miura Kouichi (日) (読)
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[継承]
2.永井 宏和
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[継承]
3. (英) Ueno Yasuharu (日) (読)
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[継承]
4. (英) Goto Takashi (日) (読)
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[継承]
5. (英) Mikami Ken-ichiro (日) (読)
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[継承]
6. (英) Nakane Kunio (日) (読)
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[継承]
7. (英) Yoneyama Kazuo (日) (読)
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[継承]
8. (英) Watanabe Daisuke (日) (読)
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9. (英) Terada Kunihiko (日) (読)
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10. (英) Sugiyama Toshihiro (日) (読)
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11. (英) Imai Katsuyuki (日) (読)
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12. (英) Senoo Haruki (日) (読)
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13. (英) Watanabe Sumio (日) (読)
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題名 (必須): (英) Epimorphin is involved in differentiation of rat hepatic stem-like cells through cell-cell contact.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Epimorphin, a mesenchymal cell surface-associated molecule, is detected on hepatic stellate cells (HSCs) in the liver. Here, we show the involvement of epimorphin in differentiation of rat hepatic stem-like cells (HSLCs) through contact with HSCs. HSLCs, isolated from adult rats, cultured in stellate cell-conditioned medium had no phenotypic and morphological changes, whereas HSLCs co-cultured with HSCs expressed albumin, transferrin, and tyrosine aminotransferase. An anti-epimorphin antibody inhibited hepatocytic differentiation of HSLCs in co-culture. Furthermore, epimorphin induced mRNA expression of albumin, transferrin, tyrosine aminotransferase, and gamma-glutamyl transpeptidase with decrease of c-kit and musashi-1. Morphologically, HSLCs piled up when co-cultured with HSCs, which was dramatically inhibited by an anti-epimorphin antibody. HSLCs contact with epimorphin started piling up, changed their shape from flat to cuboidal, and subsequently developed bile-canaliculi-like structures. In conclusion, epimorphin is a factor that induces differentiation of hepatic stem-like cells through epithelial-mesenchymal cell contact.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Communication (日) (読) [継承]
3.細胞分化 (cell differentiation) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Coculture Techniques (日) (読) [継承]
6. (英) Hepatocytes (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Membrane Glycoproteins (日) (読) [継承]
9. (英) Mesenchymal Stem Cells (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11. (英) Rats, Sprague-Dawley (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier B.V.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2003年 11月 14日 (平成 15年 11月 14日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbrc.2003.09.225    (→Scopusで検索) [継承]
PMID (任意): 14592430    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-10744227518 [継承]
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備考 (任意): 1.(英) Article.Affiliation: First Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kouichi Miura, Hirokazu Nagai, Yasuharu Ueno, Takashi Goto, Ken-ichiro Mikami, Kunio Nakane, Kazuo Yoneyama, Daisuke Watanabe, Kunihiko Terada, Toshihiro Sugiyama, Katsuyuki Imai, Haruki Senoo and Sumio Watanabe : Epimorphin is involved in differentiation of rat hepatic stem-like cells through cell-cell contact., Biochemical and Biophysical Research Communications, Vol.311, No.2, 415-423, 2003.
欧文冊子 ● Kouichi Miura, Hirokazu Nagai, Yasuharu Ueno, Takashi Goto, Ken-ichiro Mikami, Kunio Nakane, Kazuo Yoneyama, Daisuke Watanabe, Kunihiko Terada, Toshihiro Sugiyama, Katsuyuki Imai, Haruki Senoo and Sumio Watanabe : Epimorphin is involved in differentiation of rat hepatic stem-like cells through cell-cell contact., Biochemical and Biophysical Research Communications, Vol.311, No.2, 415-423, 2003.

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