| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Hayashi Shinichiro (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Sato Tomomi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Taketa Yoshikazu (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Watanabe Kouichi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Hayashi Shinji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Tanaka Sachi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Ohwada Shyuichi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Aso Hisashi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Yamaguchi Takahiro (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Myostatin and MyoD family expression in skeletal muscle of IGF-1 knockout mice. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Insulin-like growth factor-1 (IGF-1) is a positive regulator in proliferation and differentiation of skeletal muscle cells, while myostatin (MSTN) is a member of transforming growth factor beta superfamily that acts as a negative regulator of skeletal muscle mass. The present study was performed to detail whether a correlation exists between MSTN and IGF-1 in skeletal muscle of IGF-1 knockout mice (IGF-1(-/-)) and their wild type (WT; i.e., IGF-1(+/+)) littermates. The body weight of IGF-1(-/-) animals was 32% that of WT littermates. The fiber cross-sectional areas (CSA) and number of fibers in M. rectus femoris of IGF-1(-/-) animals were 49 and 59% those of WT animals, respectively. Thus, muscle hypoplasia of IGF-1(-/-) undoubtedly was confirmed. Myostatin mRNA levels and protein levels were similar between M. gastrocnemius of IGF-1(-/-) and WT animals. Myostatin immunoreactivity was similarly localized in muscle fibers of both IGF-1(-/-) and WT M. rectus femoris. The mRNA levels of MyoD family (Myf5, MyoD, MRF4, myogenin) were differentially expressed in IGF-1(-/-)M. gastrocnemius, in which the mRNA expression of MRF4 and myogenin was significantly lower, whereas there were no changes in the mRNA expression of Myf5 and MyoD. These findings first describe that myostatin expression is not influenced by intrinsic failure of IGF-1, although MRF4 and myogenin are downregulated. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Insulin-Like Growth Factor I (日) (読)
| [継承] |
| 3. | (英) Male (日) (読)
| [継承] |
| 4. | (英) Mice (日) (読)
| [継承] |
| 5. | (英) Mice, Knockout (日) (読)
| [継承] |
| 6. | (英) Muscle Strength (日) (読)
| [継承] |
| 7. | (英) Muscle, Skeletal (日) (読)
| [継承] |
| 8. | (英) MyoD Protein (日) (読)
| [継承] |
| 9. | (英) Myogenic Regulatory Factor 5 (日) (読)
| [継承] |
| 10. | (英) Myogenic Regulatory Factors (日) (読)
| [継承] |
| 11. | (英) Myogenin (日) (読)
| [継承] |
| 12. | (英) Myostatin (日) (読)
| [継承] |
| 13. | (英) RNA, Messenger (日) (読)
| [継承] |
| 14. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
| [継承] |
| 15. | (英) Transforming Growth Factor beta (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cell Biology International (International Federation for Cell Biology)
(pISSN: 1065-6995, eISSN: 1095-8355)
| ○ISSN (任意): | □ | 1065-6995
ISSN: 1065-6995
(pISSN: 1065-6995, eISSN: 1095-8355) Title: Cell biology internationalTitle(ISO): Cell Biol IntSupplier: International Federation for Cell BiologyPublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 31
| [継承] |
| ○号 (必須): | □ | 10
| [継承] |
| ○頁 (必須): | □ | 1274 1279
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2007年 5月 21日 (平成 19年 5月 21日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.cellbi.2007.05.007 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 17590360 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Affiliation: Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan. (日)
| [継承] |
| 2. | (英) PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |