『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Fukuyama Yoshiko (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) King D. Janice (日) (読)
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学籍番号 (推奨):
[継承]
3.片岡 宏介 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健福祉学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kobayashi Ryoki (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Gilbert S. Rebekah (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Oishi Kazunori (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Hollingshead K. Susan (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Briles E. David (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Fujihashi Kohtaro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae.  (日)    [継承]
副題 (任意):
要約 (任意): (英) This study was designed to investigate whether secretory-IgA (S-IgA) Abs induced by a pneumococcal surface protein A (PspA)-based nasal vaccine are necessary for prevention of streptococcal colonization. Mice nasally immunized with PspA plus a plasmid expressing Flt3 ligand (pFL) cDNA as a mucosal adjuvant showed significantly higher levels of PspA-specific S-IgA and IgG Ab responses in both plasma and nasal washes when compared with naive mice. Although IgA(-/-) mice given nasal PspA plus pFL had significantly high levels of PspA-specific IgG Abs, high numbers of CFUs were detected in nasal washes and nasal passages. In contrast, vaccinated wild-type mice showed essentially no bacteria in the nasal cavity. Further, a nasal vaccine consisting of PspA plus pFL effectively reduced pre-existing Streptococcus pneumoniae in the nasal cavity. These results show that PspA-based vaccine-induced specific S-IgA Abs play a necessary role in the regulation of S. pneumoniae colonization in the nasal cavity.  (日)    [継承]
キーワード (推奨): 1. (英) Adjuvants, Immunologic (日) (読) [継承]
2. (英) Administration, Intranasal (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Antibodies, Bacterial (日) (読) [継承]
5. (英) Bacterial Proteins (日) (読) [継承]
6. (英) Bacterial Vaccines (日) (読) [継承]
7. (英) Cells, Cultured (日) (読) [継承]
8. (英) Colony Count, Microbial (日) (読) [継承]
9. (英) Female (日) (読) [継承]
10. (英) Immunity, Innate (日) (読) [継承]
11. (英) Immunoglobulin A, Secretory (日) (読) [継承]
12. (英) Membrane Proteins (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15. (英) Mice, Knockout (日) (読) [継承]
16. (英) Streptococcal Infections (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 185 [継承]
(必須): 3 [継承]
(必須): 1755 1762 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 6月 28日 (平成 22年 6月 28日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1000831    (→Scopusで検索) [継承]
PMID (任意): 20585031    (→Scopusで検索) [継承]
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WOS (任意): 000280177400052 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pediatric Dentistry, Immunobiology Vaccine Center, Institute of Oral Health Research, University of Alabama at Birmingham, SDB 801A1, 1919 7th Avenue South, Birmingham, AL 35294-0007, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoshiko Fukuyama, Janice D. King, Kosuke Kataoka, Ryoki Kobayashi, Rebekah S. Gilbert, Kazunori Oishi, Susan K. Hollingshead, David E. Briles and Kohtaro Fujihashi : Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae., The Journal of Immunology, Vol.185, No.3, 1755-1762, 2010.
欧文冊子 ● Yoshiko Fukuyama, Janice D. King, Kosuke Kataoka, Ryoki Kobayashi, Rebekah S. Gilbert, Kazunori Oishi, Susan K. Hollingshead, David E. Briles and Kohtaro Fujihashi : Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae., The Journal of Immunology, Vol.185, No.3, 1755-1762, 2010.

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