『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学 (2004年4月1日〜) [継承]
2.徳島大学.病院.診療科.矯正歯科 (2003年10月1日〜) [継承]
3.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.中村 竜也 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
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[継承]
2.藤原 慎視
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[継承]
3.桂 智子
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[継承]
4. (英) Yamamoto Kumiko (日) 山本 久美子 (読) やまもと くみこ
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[継承]
5. (英) Inubushi Toshihiro (日) (読)
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[継承]
6.谷本 幸太郎 ([広島大学])
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[継承]
7.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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題名 (必須): (英) Effects of low-intensity pulsed ultrasound on the expression and activity of hyaluronan synthase and hyaluronidase in IL-1β-stimulated synovial cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The purpose of this study is to examine effects of low-intensity pulsed ultrasound (LIPUS) on metabolism of hyaluronan (HA) in synovial membrane cells stimulated by IL-1β. Rabbit knee synovial membrane cell line, HIG-82, was cultured in medium with the presence or absence of 1 ng/mL IL-1β, and after 4 h the cell was exposed to LIPUS for 15 min. The mRNA levels of HA synthase (HAS) 2,3, hyaluronidase (HYAL) 2, and cyclooxygenase (COX)-2 were examined by real-time PCR analysis. Concentrations of HA and PGE2 were quantified by use of enzyme linked immunosorbent assay (ELISA). The COX-2 level was analyzed by western blotting. Gene levels of HAS2 and HAS3 in IL-1β-stimulated cells were up-regulated significantly (p < 0.01) by LIPUS. HYAL2 mRNA was up-regulated by the treatment with IL-1β, whereas down-regulated significantly (p < 0.01) by the following LIPUS exposure. Furthermore, IL-1β stimulation enhanced COX-2 and PGE2 expression as compared to the untreated control, and IL-1β-induced COX-2 and PGE2 expression was inhibited by LIPUS. These results suggest that LIPUS enhanced HA synthesis and inhibited HYAL2 expression, leading to the accumulation of high-molecular weight HA. Therefore, LIPUS stimulation may be a better candidate as medical remedy to treat inflammatory joint diseases accompanied with HA degradation in synovial fluid.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Arthritis (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Cyclooxygenase 2 (日) (読) [継承]
5. (英) Dinoprostone (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Glucuronosyltransferase (日) (読) [継承]
8. (英) Hyaluronoglucosaminidase (日) (読) [継承]
9. (英) Interleukin-1beta (日) (読) [継承]
10. (英) Knee Joint (日) (読) [継承]
11. (英) Rabbits (日) (読) [継承]
12. (英) Sound (日) (読) [継承]
13. (英) Synovial Membrane (日) (読) [継承]
14. (英) Time Factors (日) (読) [継承]
15. (英) Ultrasonic Therapy (日) (読) [継承]
16. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Annals of Biomedical Engineering (Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)

ISSN (任意): 1573-9686
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 38 [継承]
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(必須): 3363 3370 [継承]
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年月日 (必須): 西暦 2010年 11月 末日 (平成 22年 11月 末日) [継承]
URL (任意):
DOI (任意): 10.1007/s10439-010-0104-5    (→Scopusで検索) [継承]
PMID (任意): 20571855    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-78149285438 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Publicationtype: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Tatsuya Nakamura, Shinji Fujihara, Tomoko Kataura, Kumiko Yamamoto, Toshihiro Inubushi, Kotaro Tanimoto and Eiji Tanaka : Effects of low-intensity pulsed ultrasound on the expression and activity of hyaluronan synthase and hyaluronidase in IL-1β-stimulated synovial cells., Annals of Biomedical Engineering, Vol.38, No.11, 3363-3370, 2010.
欧文冊子 ● Tatsuya Nakamura, Shinji Fujihara, Tomoko Kataura, Kumiko Yamamoto, Toshihiro Inubushi, Kotaro Tanimoto and Eiji Tanaka : Effects of low-intensity pulsed ultrasound on the expression and activity of hyaluronan synthase and hyaluronidase in IL-1β-stimulated synovial cells., Annals of Biomedical Engineering, Vol.38, No.11, 3363-3370, 2010.

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