| ○種別 (必須): | □ | 国際会議
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座.口腔分子生理学 (2004年4月1日〜2015年3月31日)
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| ○著者 (必須): | 1. | (英) Javkhlan, Purevjav (日) Javkhlan, Purevjav (読)
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| 2. | 廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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| 3. | (英) Ahmad, Azlina (日) Ahmad, Azlina (読)
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| 4. | 長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])
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| 5. | 姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])
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| 6. | 赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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| 7. | 木戸 淳一
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| 8. | 永田 俊彦
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| 9. | 細井 和雄
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| ○題名 (必須): | □ | (英) Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Calprotectin is a major cytosolic calcium-binding protein of leukocytes which belongs to the S100 protein family. S100A8 and S100A9, major types of calprotectin are heterodimeric complexes being composed of light- and heavy-chain subunits. The calprotectin levels in the plasma, feces, synovial fluid, gingival crevicular fluid, dental calculus and saliva change when the host animal suffers from several inflammatory diseases. Members of Toll-like receptor (TLR) family are pattern-recognition receptors for lipopolysaccharide (LPS) and other pathogens. Here we examined if the biological role of TLR receptor is reflected to the calprotectin expression in the salivary gland. Time course study by using real-time RT-PCR detected higher levels of S100A8 and S100A9 mRNA at 1.5-3 h after injection of LPS in both the submandibular gland (SMG) and parotid gland (PG) of C3H/HeN mice but not in the same tissues of C3H/HeJ, a TLR-4 mutant strain, indicating that this induction is mediated via the TLR-4. These results indicate that, an inflammatory marker, calprotectin, is expressed in the mouse salivary gland and that LPS stimulated its synthesis. Calprotectin (S100A8/A9) showed minimum expression in all cellular segments in the SMG except excretory duct cells, which showed strong signal at the cytoplasm. LPS induced their expressions in the granular convoluted tubular cells and striated duct cells. In the PG, these proteins were expressed very weakly in both duct and acinar cells with a little stronger staining for the former cells. LPS injection induced calprotectin (S100A8/A9) in both duct and acinar cells especially in the former cells. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Calgranulin A (日) (読)
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| 3. | (英) Calgranulin B (日) (読)
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| 4. | (英) Leukocyte L1 Antigen Complex (日) (読)
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| 5. | (英) Lipopolysaccharides (日) (読)
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| 6. | (英) Mice (日) (読)
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| 7. | (英) Mice, Inbred C3H (日) (読)
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| 8. | (英) Mice, Mutant Strains (日) (読)
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| 9. | (英) Parotid Gland (日) (読)
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| 10. | (英) RNA, Messenger (日) (読)
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| 11. | 唾液腺 (salivary glands/->キーワード[唾液腺])
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| 12. | (英) Submandibular Gland (日) (読)
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| 13. | (英) Toll-Like Receptor 4 (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 56
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| ○号 (必須): | □ | Suppl
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| ○頁 (必須): | □ | 287 289
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| ○都市 (必須): | □ | 徳島 (Tokushima/[日本国])
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| ○年月日 (必須): | □ | 西暦 2009年 12月 初日 (平成 21年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.56.287 (→Scopusで検索)
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| ○PMID (任意): | □ | 20224205 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
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| ○機関リポジトリ : | □ | 111354
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) The 11th International Symposium on Exocrine Secretion, Tokushima 09 ''Exocrine Secretion Mechanism and Disease'' (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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