『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=213738EID:213738, Map:0, LastModified:2012年8月29日(水) 12:07:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[阿部 真治], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kishuku Masatoshi (日) (読)
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2.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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3.阿部 真治 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.総合薬学教育学系.臨床薬学実務教育学])
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4.岸 潤
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5. (英) Ogino Hirokazu (日) (読)
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6.青野 純典 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座.呼吸器・膠原病内科学])
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7.東 桃代 ([徳島大学.病院.中央診療施設等.感染制御部])
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8.木下 勝弘
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9. (英) Batmunkh Rentsenkhand (日) (読)
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10. (英) Rentsenhand Batmungh (日) (読)
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11. (英) Makino Hideki (日) (読)
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12. (英) Ranjan Priya (日) (読)
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13.水口 和生
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14.曽根 三郎
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題名 (必須): (英) Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The soluble form of vascular endothelial growth factor receptor-1 (sVEGFR-1) is produced from endothelial cells by alternative splicing of VEGFR-1 mRNA, and can inhibit angiogenesis by blocking the biological effects of VEGF. In this study, we show the expression of a large amount of sVEGFR-1 in human monocyte-derived mature dendritic cells (mDCs). As compared with monocytes and immature DCs, mDCs generated by TNF-alpha or soluble CD40L with IFN-gamma, but not LPS or other stimuli, preferentially produce sVEGFR-1. We also detected the mRNA of sVEGFR-1 generated by alternative splicing of VEGFR-1 mRNA in mDCs induced by TNF-alpha. The production of sVEGFR-1 showed a distinct contrast to those of VEGF in each DC matured with various stimuli. The supernatant of DCs matured with TNF-alpha or soluble CD40L with IFN-gamma showed inhibition of the tube formation of HUVECs, which was neutralized by anti-VEGFR-1 Ab, indicating that sVEGFR-1 secreted from mDCs was biologically active. Interestingly, the supernatant of mDCs generated with LPS increased HUVEC capillary-like formation in vitro. The ratio of sVEGFR-1 to VEGF clearly reflected the net angiogenic property of mDCs. Administration of mDCs induced by TNF-alpha into the s.c. tumor of PC-14 cells implanted in SCID mice demonstrated the inhibition of tumor growth via reduction of the number of CD31-positive vessels, indicating their in vivo antiangiogenic potential. These results suggest that sVEGFR-1 produced by mDCs contribute to their antiangiogenic property, and the ratio of sVEGFR-1 to VEGF might be a useful tool for evaluating their ability to regulate angiogenesis mediated by VEGF.  (日)    [継承]
キーワード (推奨): 1. (英) Angiogenesis Inhibitors (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Dendritic Cells (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, SCID (日) (読) [継承]
12. (英) Monocytes (日) (読) [継承]
13. (英) Neoplasm Transplantation (日) (読) [継承]
14. (英) Vascular Endothelial Growth Factor A (日) (読) [継承]
15. (英) Vascular Endothelial Growth Factor Receptor-1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 183 [継承]
(必須): 12 [継承]
(必須): 8176 8185 [継承]
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年月日 (必須): 西暦 2009年 12月 15日 (平成 21年 12月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0803849    (→Scopusで検索) [継承]
PMID (任意): 20007583    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Respiratory Medicine and Rheumatology, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) CommentsCorrectionsList.CommentsCorrections.RefSource: J Immunol. 2010 Aug 15;185(4):2630  (日)    [継承]
6.(英) CommentsCorrectionsList.CommentsCorrections.Note: Rentsenhand, Batmungh [corrected to Batmunkh, Rentsenkhand]  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Masatoshi Kishuku, Yasuhiko Nishioka, Shinji Abe, Jun Kishi, Hirokazu Ogino, Yoshinori Aono, Momoyo Azuma, Katsuhiro Kinoshita, Rentsenkhand Batmunkh, Batmungh Rentsenhand, Hideki Makino, Priya Ranjan, Kazuo Minakuchi and Saburo Sone : Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property., The Journal of Immunology, Vol.183, No.12, 8176-8185, (発行所), (都市), Dec. 2009.
欧文冊子 ● (種別) : Masatoshi Kishuku, Yasuhiko Nishioka, Shinji Abe, Jun Kishi, Hirokazu Ogino, Yoshinori Aono, Momoyo Azuma, Katsuhiro Kinoshita, Rentsenkhand Batmunkh, Batmungh Rentsenhand, Hideki Makino, Priya Ranjan, Kazuo Minakuchi and Saburo Sone : Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property., The Journal of Immunology, Vol.183, No.12, 8176-8185, (発行所), (都市), Dec. 2009.

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