『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Rayhan Nasim (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.佐野 壽昭
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[継承]
3.銭 志栄
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学籍番号 (推奨):
[継承]
4. (英) Obari Abdul Kader (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5.廣川 満良
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題名 (必須): (英) Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Composite neuroendocrine-exocrine carcinomas (NEECs) with two distinct components of adenocarcinoma and neuroendocrine (NE) carcinoma within the same tumor are rare but may have a clue for clarifying the pathogenesis of NE tumors arising from non-endocrine organs. This study was done to characterize histological and immunohistochemical features of NEECs of the stomach comparing with pure NE tumors of the gastrointestinal (GI) tract. Microscopically, adenocarcinoma components in 6 of 8 NEECs were well differentiated and located superficially, whereas NE components were poorly differentiated and located deeply. In the remaining two cases, smaller NE components were intermingled within adenocarcinoma components. Immunohistochemically, neural cell adhesion molecule (NCAM) was positive in 5 NE components, of which 3 cases were homogeneously positive, and 2 adenocarcinoma components of 8 NEECs, while 19 of 21 pure NE tumors of GI tract were homogeneously positive for NCAM. Ghrelin-immunoreactivity was found in 4 NE components and 2 adenocarcinoma components of NEECs, although 20 pure NE tumors were positive for ghrelin. Smad4 was positive in both components of 7 NEECs. These findings suggest that composite NEECs and pure NE tumors of GI tract may have different NE properties and that most NE components of composite NEECs of the stomach may originate from an adenocarcinoma precursor cell and occasional tumors from a pluripotent cell.  (日)    [継承]
キーワード (推奨): 1. (英) Adenocarcinoma (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Aged, 80 and over (日) (読) [継承]
4. (英) Carcinoma, Neuroendocrine (日) (読) [継承]
5. (英) DNA-Binding Proteins (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Ghrelin (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.免疫組織化学 (immunohistochemistry) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Neural Cell Adhesion Molecules (日) (読) [継承]
13. (英) Peptide Hormones (日) (読) [継承]
14. (英) Smad4 Protein (日) (読) [継承]
15. (英) Stomach Neoplasms (日) (読) [継承]
16. (英) Trans-Activators (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 52 [継承]
(必須): 3-4 [継承]
(必須): 191 202 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 8月 1日 (平成 17年 8月 1日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.52.191    (→Scopusで検索) [継承]
PMID (任意): 16167538    (→Scopusで検索) [継承]
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機関リポジトリ : 110777 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Nasim Rayhan, Toshiaki Sano, Zhi-Rong Qian, Kader Abdul Obari and Mitsuyoshi Hirokawa : Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach., The Journal of Medical Investigation : JMI, Vol.52, No.3-4, 191-202, 2005.
欧文冊子 ● Nasim Rayhan, Toshiaki Sano, Zhi-Rong Qian, Kader Abdul Obari and Mitsuyoshi Hirokawa : Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach., The Journal of Medical Investigation : JMI, Vol.52, No.3-4, 191-202, 2005.

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