| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hossain M Golam (日) (読)
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| 2. | 岩田 武男
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| 3. | 水澤 典子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 4. | 銭 志栄
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| 5. | (英) Shima Shahidan Wan Nazatul (日) (読)
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| 6. | (英) Okutsu Toru (日) (読)
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| 7. | (英) Yamada Shozo (日) (読)
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| 8. | 佐野 壽昭
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| 9. | 吉本 勝彦
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| ○題名 (必須): | □ | (英) Expression of p18(INK4C) is down-regulated in human pituitary adenomas. (日)
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| ○要約 (任意): | □ | (英) Cyclin-dependent kinase inhibitors represented by the INK4 family comprising p16(INK4A), p15(INK4B), p18(INK4C), and p19(INK4D) are regulators of the cell cycle shown to be aberrant in many types of cancer. Mice lacking p18(Ink4c) exhibit a series of phenotypes including the development of widespread organomegaly and pituitary adenomas. The objective of our study is to examine the role of p18(INK4C) in the pathogenesis of human pituitary tumors. The protein and mRNA levels of p18(INK4C) were examined by immunohistochemistry and real-time reverse transcription-polymerase chain reaction, respectively. The methylation status of the p18(INK4C) gene promoter and somatic mutations of the p18(INK4C) gene were also investigated. p18(INK4C) protein expression was lost or significantly reduced in 64% of pituitary adenomas compared with levels in normal pituitary glands. p18(INK4C) mRNA levels were low in all ACTH adenomas and non-functioning (NF)-FSH and in 42%, 70% and 66% of GH, PRL, and subtype 3 adenomas, respectively. p18(INK4C) mRNA levels were significantly associated with p18(INK4C) protein levels. Neither methylated promoters in pituitary adenomas, except in one NF-FSH adenoma, nor somatic mutations of the p18(INK4C) gene in any pituitary adenomas were detected. The down-regulation of p18(INK4C) expression may contribute to the tumorigenesis of pituitary adenomas. (日)
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| ○キーワード (推奨): | 1. | (英) Adenoma (日) (読)
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| 2. | (英) Adult (日) (読)
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| 3. | (英) Aged (日) (読)
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| 4. | (英) Aged, 80 and over (日) (読)
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| 5. | (英) Cyclin-Dependent Kinase Inhibitor p18 (日) (読)
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| 6. | (英) DNA Methylation (日) (読)
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| 7. | (英) Down-Regulation (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Gene Expression Regulation, Neoplastic (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Middle Aged (日) (読)
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| 13. | (英) Mutation (日) (読)
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| 14. | (英) Pituitary Neoplasms (日) (読)
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| 15. | (英) RNA, Messenger (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Endocrine Pathology (Endocrine Pathology Society)
(pISSN: 1046-3976, eISSN: 1559-0097)
| ○ISSN (任意): | □ | 1046-3976
ISSN: 1046-3976
(pISSN: 1046-3976, eISSN: 1559-0097) Title: Endocrine pathologyTitle(ISO): Endocr PatholSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 114 121
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 8月 10日 (平成 21年 8月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s12022-009-9076-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 19401813 (→Scopusで検索)
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| ○WOS (任意): | □ | 000266261200005
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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