『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=210563)

EID=210563EID:210563, Map:0, LastModified:2012年8月28日(火) 21:42:23, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[久保 宜明], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hida Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kubo Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Arase S (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours.  (日)    [継承]
副題 (任意):
要約 (任意): (英) BACKGROUND: The activation of oncogenes is an important step in tumorigenesis, and recently, oncogene-induced senescence (OIS) was proposed as a critical barrier against malignant transformation in normal primary cells. OBJECTIVES: The aim of this study was to examine the activation of fibroblast growth factor receptor 3 (FGFR3) as an oncogene product and OIS in human skin tumours. METHODS: We investigated the activation of FGFR3 and OIS by mutation and immunohistochemical analysis in skin tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen's disease (BD), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). RESULTS: Activated point mutations of FGFR3 were identified in four of 22 cases (18%) of seborrhoeic keratosis, but no mutation was detected in the other skin tumours. Twenty-seven of 31 cases (87%) of seborrhoeic keratosis showed moderately to strongly positive expression of the FGFR3 protein, but almost all the other skin tumours were negative. On the other hand, almost all the seborrhoeic keratoses showed negative immunoreactivity for antiphoshohistone H2AX (gamma-H2AX) as a marker of OIS, but 17 of 22 cases (77%) of AK were moderately to strongly positive. Immunoreactivity for gamma-H2AX was significantly greater in AK than in seborrhoeic keratosis, BD, BCC and SCC. CONCLUSIONS: The activation of FGFR3 might be a common feature in the tumorigenesis in seborrhoeic keratosis, although the activation does not induce a typical oncogenic signal in keratinocytes. In addition, OIS due to some oncogenic signals rather than activation of FGFR3 might be involved in the early skin carcinogenesis related to chronic ultraviolet radiation exposure.  (日)    [継承]
キーワード (推奨): 1. (英) Bowen's Disease (日) (読) [継承]
2. (英) Carcinoma, Basal Cell (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Chi-Square Distribution (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Keratosis, Actinic (日) (読) [継承]
7. (英) Keratosis, Seborrheic (日) (読) [継承]
8. (英) Oncogenes (日) (読) [継承]
9. (英) Point Mutation (日) (読) [継承]
10. (英) Receptor, Fibroblast Growth Factor, Type 3 (日) (読) [継承]
11. (英) Skin Aging (日) (読) [継承]
12. (英) Skin Neoplasms (日) (読) [継承]
13. (英) Transcriptional Activation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The British Journal of Dermatology (British Association of Dermatologists)
(pISSN: 0007-0963, eISSN: 1365-2133)

ISSN (任意): 1365-2133
ISSN: 0007-0963 (pISSN: 0007-0963, eISSN: 1365-2133)
Title: The British journal of dermatology
Title(ISO): Br J Dermatol
Supplier: British Association of Dermatologists
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 160 [継承]
(必須): 6 [継承]
(必須): 1258 1263 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 3月 9日 (平成 21年 3月 9日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2133.2009.09068.x    (→Scopusで検索) [継承]
PMID (任意): 19298285    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Y Hida, Y Kubo and S Arase : Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours., The British Journal of Dermatology, Vol.160, No.6, 1258-1263, (発行所), (都市), March 2009.
欧文冊子 ● (種別) : Y Hida, Y Kubo and S Arase : Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours., The British Journal of Dermatology, Vol.160, No.6, 1258-1263, (発行所), (都市), March 2009.

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