『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=210226EID:210226, Map:0, LastModified:2018年3月2日(金) 17:08:29, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[野間口 雅子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nagao Tamiko (日) (読)
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[継承]
2. (英) Hatcho Kazuki (日) (読)
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[継承]
3. (英) Doi Naoya (日) (読)
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[継承]
4. (英) Fujiwara Sachi (日) (読)
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[継承]
5.足立 昭夫
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[継承]
6.野間口 雅子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])
役割 (任意):
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Amino acid alterations in Gag that confer the ability to grow in simian cells on HIV-1 are located at a narrow CA region.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We previously generated a prototype monkey-tropic human immunodeficiency virus type 1 (HIV-1) designated NL-DT5R. This viral clone has a small region of simian immunodeficiency virus (SIV) within Gag capsid (CA) protein and also SIV Vif protein, but displays a poor growth phenotype in simian cells. To improve the growth potential of NL-DT5R, we have constructed a series of its gag variant viruses. Out of fourteen viral clones generated, five were infectious for simian HSC-F cells, and two of the infectious variants grew similarly with NL-DT5R. Taking their genome structures into consideration, our data here clearly show that a narrow CA region within the Gag protein, i.e., the domain around cyclophilin A (CypA)-binding loop, is critical for the growth ability of HIV-1 in simian cells.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Amino Acids (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Cell Proliferation (日) (読) [継承]
6. (英) Cyclophilin A (日) (読) [継承]
7. (英) Disease Models, Animal (日) (読) [継承]
8. (英) Epithelial Cells (日) (読) [継承]
9. (英) Gene Products, gag (日) (読) [継承]
10. (英) Gene Products, vif (日) (読) [継承]
11. (英) HIV-1 (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Macaca fascicularis (日) (読) [継承]
14. (英) Molecular Sequence Data (日) (読) [継承]
15. (英) Mutation (日) (読) [継承]
16. (英) Simian immunodeficiency virus (日) (読) [継承]
17. (英) T-Lymphocytes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 56 [継承]
(必須): 1-2 [継承]
(必須): 21 25 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 2月 初日 (平成 21年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.56.21    (→Scopusで検索) [継承]
PMID (任意): 19262010    (→Scopusで検索) [継承]
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機関リポジトリ : 110880 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Virology, Institute of Health Biosciences, the University of Tokushima Graduate School, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tamiko Nagao, Kazuki Hatcho, Naoya Doi, Sachi Fujiwara, Akio Adachi and Masako Nomaguchi : Amino acid alterations in Gag that confer the ability to grow in simian cells on HIV-1 are located at a narrow CA region., The Journal of Medical Investigation : JMI, Vol.56, No.1-2, 21-25, 2009.
欧文冊子 ● Tamiko Nagao, Kazuki Hatcho, Naoya Doi, Sachi Fujiwara, Akio Adachi and Masako Nomaguchi : Amino acid alterations in Gag that confer the ability to grow in simian cells on HIV-1 are located at a narrow CA region., The Journal of Medical Investigation : JMI, Vol.56, No.1-2, 21-25, 2009.

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