『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日) [継承]
2.広島大学 [継承]
著者 (必須): 1. (英) Nakatani Yuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.谷本 幸太郎 ([広島大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Tanaka Nobuaki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Tanne Yuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kamiya Takashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Kunimatsu Ryo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.丹根 一夫 ([広島大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) It is well known that low-molecular weight hyaluronan (HA) is detected in human periodontal tissue under inflammatory conditions. HA oligosaccharide (HAoligo) has been demonstrated to induce matrix metalloproteinase (MMP)-1 expression in dendritic cells and chondrocytes, however, the bioactivities of HAoligo in periodontal ligament (PDL) cells remain unclear. In this study, we investigated the effect of HAoligo on MMP-1 expression in human PDL (HPDL) cells and the mechanisms in terms of the signal transmission. HAoligo was generated and purified from commercial human umbilical cord HA. HPDL cells were isolated from healthy ligaments, and cultured with HAoligo for 0-24h. The expression of MMP-1, tissue inhibitor of MMPs (TIMP)-1 and TIMP-2 was analyzed by real-time PCR and Western blot analyses. Effects of specific inhibitors of p38 mitogen-activated protein kinase (MAPK) activity, MAPK kinase activity and NFkB activity on HAoligo-induced MMP-1 expression in HPDL cells were also investigated by real-time PCR and Western blot analyses. HAoligo remarkably enhanced MMP-1 expression in both mRNA and protein levels, but no effect was shown on the expression of TIMP-1 and TIMP-2 mRNAs. Inhibition of p38MAPK activity decreased the MMP-1 expression. Neither inhibition of NFkB nor MAPKK activity affected the MMP-1 expression. It was suggested that HAoligo induces MMP-1 expression in HPDL cells, and p38MAPK plays a crucial role in signal transduction for MMP-1 inducted by HAoligo  (日)    [継承]
キーワード (推奨): 1. (英) Anti-Inflammatory Agents (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Dose-Response Relationship, Drug (日) (読) [継承]
4. (英) Enzyme Inhibitors (日) (読) [継承]
5.フラボノイド (flavonoids) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Hyaluronic Acid (日) (読) [継承]
8. (英) Imidazoles (日) (読) [継承]
9. (英) Matrix Metalloproteinase 1 (日) (読) [継承]
10. (英) Mitogen-Activated Protein Kinase Kinases (日) (読) [継承]
11. (英) NF-kappa B (日) (読) [継承]
12. (英) Oligosaccharides (日) (読) [継承]
13. (英) Periodontal Ligament (日) (読) [継承]
14. (英) Pyridines (日) (読) [継承]
15. (英) Sesquiterpenes (日) (読) [継承]
16.シグナル伝達 (signal transduction) [継承]
17. (英) Tissue Inhibitor of Metalloproteinase-1 (日) (読) [継承]
18. (英) Tissue Inhibitor of Metalloproteinase-2 (日) (読) [継承]
19. (英) p38 Mitogen-Activated Protein Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Archives of Oral Biology ([Elsevier])
(pISSN: 0003-9969, eISSN: 1879-1506)

ISSN (任意): 1879-1506
ISSN: 0003-9969 (pISSN: 0003-9969, eISSN: 1879-1506)
Title: Archives of oral biology
Title(ISO): Arch Oral Biol
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 54 [継承]
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(必須): 757 763 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 8月 末日 (平成 21年 8月 末日) [継承]
URL (任意):
DOI (任意): 10.1016/j.archoralbio.2009.05.005    (→Scopusで検索) [継承]
PMID (任意): 19523610    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000267999500008 [継承]
Scopus (任意):
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指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yuki Nakatani, Kotaro Tanimoto, Nobuaki Tanaka, Yuki Tanne, Takashi Kamiya, Ryo Kunimatsu, Eiji Tanaka and Kazuo Tanne : Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells, Archives of Oral Biology, Vol.54, No.8, 757-763, 2009.
欧文冊子 ● Yuki Nakatani, Kotaro Tanimoto, Nobuaki Tanaka, Yuki Tanne, Takashi Kamiya, Ryo Kunimatsu, Eiji Tanaka and Kazuo Tanne : Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells, Archives of Oral Biology, Vol.54, No.8, 757-763, 2009.

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