『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.木平 孝高
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学籍番号 (推奨):
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2. (英) Hermanstyne O. Tracey (日) (読)
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3. (英) Misonou Hiroaki (日) (読)
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題名 (必須): (英) Formation of heteromeric Kv2 channels in mammalian brain neurons  (日)    [継承]
副題 (任意):
要約 (任意): (英) The formation of heteromeric tetramers is a common feature of voltage-gated potassium (Kv) channels. This results in the generation of a variety of tetrameric Kv channels that exhibit distinct biophysical and biochemical characteristics. Kv2 delayed rectifier channels are, however, unique exceptions. It has been previously shown that mammalian Kv2.1 and Kv2.2 are localized in distinct domains of neuronal membranes and are not capable of forming heteromeric channels with each other (Hwang, P. M., Glatt, C. E., Bredt, D. S., Yellen, G., and Snyder, S. H. (1992) Neuron 8, 473-481). In this study, we report a novel form of rat Kv2.2, Kv2.2(long), which has not been previously recognized. Our data indicate that Kv2.2(long) is the predominant form of Kv2.2 expressed in cortical pyramidal neurons. In contrast to the previous findings, we also found that rat Kv2.1 and Kv2.2(long) are colocalized in the somata and proximal dendrites of cortical pyramidal neurons and are capable of forming functional heteromeric delayed rectifier channels. Our results suggest that the delayed rectifier currents, which regulate action potential firing, are encoded by heteromeric Kv2 channels in cortical neurons.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Base Sequence (日) (読) [継承]
4. (brain) [継承]
5.免疫組織化学 (immunohistochemistry) [継承]
6. (英) Immunoprecipitation (日) (読) [継承]
7. (英) Molecular Sequence Data (日) (読) [継承]
8. (英) Mutation (日) (読) [継承]
9. (英) Neurons (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11. (英) Sequence Homology, Amino Acid (日) (読) [継承]
12. (英) Sequence Homology, Nucleic Acid (日) (読) [継承]
13. (英) Shab Potassium Channels (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 285 [継承]
(必須): 20 [継承]
(必須): 15048 15055 [継承]
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年月日 (必須): 西暦 2010年 3月 4日 (平成 22年 3月 4日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M109.074260    (→Scopusで検索) [継承]
PMID (任意): 20202934    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-77952050675 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Neural and Pain Sciences, Dental School, University ofMaryland, Baltimore, Maryland 21201, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) OtherID: PMC2865335  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Kihira, Tracey O. Hermanstyne and Hiroaki Misonou : Formation of heteromeric Kv2 channels in mammalian brain neurons, The Journal of Biological Chemistry, Vol.285, No.20, 15048-15055, 2010.
欧文冊子 ● Yoshitaka Kihira, Tracey O. Hermanstyne and Hiroaki Misonou : Formation of heteromeric Kv2 channels in mammalian brain neurons, The Journal of Biological Chemistry, Vol.285, No.20, 15048-15055, 2010.

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