『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=193717)

EID=193717EID:193717, Map:0, LastModified:2012年9月27日(木) 21:35:30, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[新垣 尚捷], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kita Toshiyuki (日) (読)
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2. (英) Nishida Hana (日) (読)
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3. (英) Shibata Hirofumi (日) (読)
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4. (英) Niimi Shingo (日) (読)
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5. (英) Higuti Tomihiko (日) (読)
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6.新垣 尚捷
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題名 (必須): (英) Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mitochondrial fusion and fission processes play a role in a variety of cell functions, including energy metabolism, cell differentiation and programmed cell death. Still, it is not clear how these processes contribute to the cell functions. Here, we investigated the role of mitochondrial remodelling on lipid metabolism in adipocytes. In 3T3-L1 pre-adipocytes, the morphology of mitochondria is organized as a continuous reticulum. Upon differentiation of adipocytes manifested by cellular triacylglycerol (TG) accumulation, mitochondrial morphology altered from filamentous to fragmented and/or punctate structures. When the mitochondrial fusion was induced in adipocytes by silencing of mitochondrial fission proteins including Fis1 and Drp1, the cellular TG content was decreased. In contrast, the silencing of mitochondrial fusion proteins including mitofusin 2 and Opa1 increased the cellular TG content followed by fragmentation of mitochondria. It also appears that polyphenolic phytochemicals, negative regulators of lipid accumulation, have mitochondrial fusion activity and that there is a good correlation between mitochondrial fusion activity and the cellular TG accumulation-reducing activity of the phytochemicals. These results suggest that cellular TG accumulation is regulated, at least in part, via mitochondrial fusion and fission processes.  (日)    [継承]
キーワード (推奨): 1. (英) Adipocytes (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Base Sequence (日) (読) [継承]
4. (英) Cell Differentiation (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Membrane Fusion (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Microscopy, Fluorescence (日) (読) [継承]
10. (英) Mitochondria (日) (読) [継承]
11. (英) Mitochondrial Proteins (日) (読) [継承]
12. (英) Molecular Sequence Data (日) (読) [継承]
13. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
14. (英) Triglycerides (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biochemistry ([日本生化学会])
(pISSN: 0021-924X, eISSN: 1756-2651)

ISSN (任意): 1756-2651
ISSN: 0021-924X (pISSN: 0021-924X, eISSN: 1756-2651)
Title: Journal of biochemistry
Title(ISO): J Biochem
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2009年 9月 初日 (平成 21年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1093/jb/mvp124    (→Scopusで検索) [継承]
PMID (任意): 19671539    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Cell Biology and Medicine, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima 770-8505, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Toshiyuki Kita, Hana Nishida, Hirofumi Shibata, Shingo Niimi, Tomihiko Higuti and Naokatu Arakaki : Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation., The Journal of Biochemistry, Vol.146, No.6, 787-796, 2009.
欧文冊子 ● Toshiyuki Kita, Hana Nishida, Hirofumi Shibata, Shingo Niimi, Tomihiko Higuti and Naokatu Arakaki : Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation., The Journal of Biochemistry, Vol.146, No.6, 787-796, 2009.

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