| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 川中 崇 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学]/[徳島大学.病院.診療科.放射線科.放射線治療科])
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| 2. | 久保 亜貴子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学]/[徳島大学.病院.診療科.放射線科])
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| 3. | 生島 仁史 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.放射線治療学])
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| 4. | 佐野 壽昭
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| 5. | 竹川 佳宏
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| 6. | 西谷 弘
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| ○題名 (必須): | □ | (英) Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy. (日)
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| ○要約 (任意): | □ | (英) Hypoxia-inducible factor (HIF)-2alpha, a basic helix-loop-helix (bHLH)-PAS protein, is the principal regulator of the hypoxic transcriptional response. An immunohistochemical study reported strong HIF-2alpha expression in the cytoplasm of tumor infiltrative macrophages (TIMs). Thus we assessed the expression of HIF-2alpha in human cervical cancer tissue before radiation therapy and its relationship to the clinical outcome. Seventy three patients with histologically proven primary advanced squamous cell carcinoma of the uterine cervix underwent radiotherapy in Tokushima University Hospital after biopsy specimens were taken. Among 73 specimens stained for HIF-2alpha, 53 (72.6%) exhibited HIF-2alpha immunoreactivity in the TIMs. In only 5 of 73 cases, HIF-2alpha immunoreactivity was observed in the nuclei of tumor cells. The HIF-2alpha positive cell count ratio in TIMs was associated with disease-free survival (DFS) with the worst DFS (p=0.024) being in cases in the group with a high positive cell count ratio. A high HIF-2alpha positive cell count ratio in TIMs increased the risk of local recurrence (p=0.0142). These findings might suggest that the ratio of the HIF-2alpha positive cell in TIMs may be a new predictive indicator for prognosis before radiation therapy for uterine cervical cancer. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aged, 80 and over (日) (読)
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| 4. | (英) Basic Helix-Loop-Helix Transcription Factors (日) (読)
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| 5. | (英) Carcinoma, Squamous Cell (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Gene Expression Regulation, Neoplastic (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Macrophages (日) (読)
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| 10. | (英) Middle Aged (日) (読)
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| 11. | (英) Predictive Value of Tests (日) (読)
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| 12. | (英) Prognosis (日) (読)
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| 13. | (英) Retrospective Studies (日) (読)
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| 14. | (英) Tumor Markers, Biological (日) (読)
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| 15. | (英) Uterine Neoplasms (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1343-1420
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
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(医中誌Web)
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(Scopus)
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| ○巻 (必須): | □ | 55
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| ○号 (必須): | □ | 1-2
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| ○頁 (必須): | □ | 78 86
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 2月 初日 (平成 20年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.55.78 (→Scopusで検索)
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| ○PMID (任意): | □ | 18319549 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 110842
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Radiology, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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