| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sakai T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Horii T (日) (読)
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| [継承] |
| 3. | (英) Hisaeda H (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Zhang M (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Ishii K (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Nakano Y (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 前川 洋一
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Izumi K (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Nitta Y (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Miyazaki J (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Himeno K (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinoculation of cytokine expression plasmid. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We immunized mice with plasmid expressing the 47-kDa amino-terminal domain of the Plasmodium falciparum serine repeat antigen (SERA) using gene gun and investigated humoral immune response to SERA antigen. Significant SERA-specific IgG was observed in BALB/c mice after immunization three times with SERA expression plasmid. Furthermore, these levels were increased by the coinoculation of cytokine (IFN-gamma, IL-4, GM-CSF, or IL-12) expression plasmid. In respect to the SERA-specific Ig subclasses, coinoculation of IFN-gamma, GM-CSF, or IL-12 expression plasmid increased the levels of SERA-specific IgG2a, and these were much higher than that in mice immunized with SERA expression plasmid alone. In contrast to the SERA-specific IgG2a, coinoculation of any cytokine expression plasmid did not change the levels of SERA-specific IgG1. These results indicate that cytokine expression plasmid enhances and regulates humoral immune response elicited by SERA DNA immunization. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibodies, Protozoan (日) (読)
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| 3. | (英) Antigens, Protozoan (日) (読)
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| 4. | (英) Biolistics (日) (読)
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| 5. | 細胞質分裂 (cytokinesis)
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| 6. | (英) Malaria Vaccines (日) (読)
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| 7. | (英) Malaria, Falciparum (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Mice, Inbred BALB C (日) (読)
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| 10. | (英) Plasmids (日) (読)
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| 11. | (英) Plasmodium falciparum (日) (読)
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| 12. | (英) Vaccination (日) (読)
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| 13. | (英) Vaccines, DNA (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Parasitology International ([日本寄生虫学会])
(pISSN: 1383-5769, eISSN: 1873-0329)
| ○ISSN (任意): | □ | 1383-5769
ISSN: 1383-5769
(pISSN: 1383-5769, eISSN: 1873-0329) Title: Parasitology internationalTitle(ISO): Parasitol IntPublisher: Elsevier Ireland Ltd (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 48
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 27 33
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1999年 3月 初日 (平成 11年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 11269323 (→Scopusで検索)
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| ○CRID (任意): |
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| ○researchmap (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Parasitology and Immunology, University of Tokushima School of Medicine, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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