| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Ishikawa Tohru (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Nakashiro Koh-ichi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Klosek K. Sebastian (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) Goda Hiroyuki (日) (読)
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| ○貢献度 (任意): |
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| 5. | (英) Hara Shingo (日) (読)
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| ○貢献度 (任意): |
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| 6. | 内田 大亮
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| ○貢献度 (任意): |
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| 7. | (英) Hamakawa Hiroyuki (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Hypoxia promotes the invasive and metastatic potential of tumour cells. A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent. We have previously demonstrated that CXCR4 signalling is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (OSCC). In this study, we investigated a correlation between CXCR4 and HIF-1alpha expression in OSCC. Immunohistochemistry showed that CXCR4 was expressed in 20 of 85 OSCC tissues, while HIF-1alpha was expressed in 51 of 85 samples. There was a significant correlation between the expression of CXCR4 and HIF-1alpha. In human OSCC cells, hypoxia markedly enhanced the expression of both HIF-1alpha and CXCR4. Furthermore, synthetic small interfering RNA specific for HIF-1alpha significantly suppressed the expression of this protein, and also attenuated the induction of CXCR4 expression under hypoxic conditions. These results indicated that HIF-1alpha regulated hypoxia-induced CXCR4 expression in OSCC. (日)
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| ○キーワード (推奨): | 1. | (英) Blotting, Western (日) (読)
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| 2. | (英) Carcinoma, Squamous Cell (日) (読)
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| 3. | (英) Cell Hypoxia (日) (読)
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| 4. | (英) Gene Expression Regulation, Neoplastic (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Hypoxia-Inducible Factor 1, alpha Subunit (日) (読)
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| 7. | 免疫組織化学 (immunohistochemistry)
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| 8. | (英) Middle Aged (日) (読)
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| 9. | (英) Mouth Neoplasms (日) (読)
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| 10. | (英) RNA, Small Interfering (日) (読)
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| 11. | (英) Receptors, CXCR4 (日) (読)
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| 12. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Oncology Reports (Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)
| ○ISSN (任意): | □ | 1021-335X
ISSN: 1021-335X
(pISSN: 1021-335X, eISSN: 1791-2431) Title: Oncology reportsTitle(ISO): Oncol. Rep.Publisher: Spandidos Publications (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 21
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 707 712
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 3月 初日 (平成 21年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3892/or_00000275 (→Scopusで検索)
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| ○PMID (任意): | □ | 19212630 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): | □ | 000263584000018
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| ○Scopus (任意): | □ | 2-s2.0-64849114878
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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