| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kirino Yasushi (日) (読)
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| 2. | (英) Kamimoto Takayuki (日) (読)
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| 3. | 佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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| 4. | 川添 和義
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| 5. | 水口 和生
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| 6. | 中堀 豊
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| ○題名 (必須): | □ | (英) Increased Plasma Dipeptidyl Peptidase IV (DPP IV) Activity and Decreased DPP IV Activity of Visceral But Not Subcutaneous Adipose Tissue in Impaired Glucose Tolerance Rats Induced by High-Fat or High-Sucrose Diet (日)
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| ○要約 (任意): | □ | (英) Several studies have investigated whether dipeptidyl peptidase IV (DPP IV) activity is correlated to the severity of diabetes; however, it remains unclear. To investigate the roles of DPP IV activity in metabolic abnormalities, impaired glucose tolerance rats were produced using a high-fat (HF) or high-sucrose (HS) diet. HF diet-fed rats obviously exhibited impaired glucose tolerance, with increases in subcutaneous and epididymal fat mass, insulin resistance and dyslipidaemia. In rats fed a HS diet rather than a normal diet, lower body weight and fasting blood glucose were observed temporarily in the early period after HS diet feeding; however, impaired glucose tolerance was evoked to some extent with an increase in epididymal fat mass. Both HF and HS diet-fed rats showed significantly higher plasma DPP IV activity than normal diet-fed rats, in the order of HF diet>HS diet>normal diet. HF and HS diets did not significantly affect DPP IV activity and mRNA expression in the kidney. On the other hand, HF, but not HS, diet caused a significant decrease in DPP IV activity in the liver as compared to the control. Of note, both HF and HS diets caused a significant decrease in DPP IV activity in epididymal fat, even though they did not change DPP IV activity in subcutaneous fat. In conclusion, HF or HS diet-induced impaired glucose tolerance with visceral fat accumulation may be interrelated with increased plasma DPP IV activity and decreased DPP IV activity of visceral but not subcutaneous adipose tissue. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Body Weight (日) (読)
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| 3. | (英) Dietary Fats (日) (読)
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| 4. | (英) Dietary Sucrose (日) (読)
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| 5. | (英) Dipeptidyl Peptidase 4 (日) (読)
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| 6. | (英) Eating (日) (読)
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| 7. | (英) Glucose Intolerance (日) (読)
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| 8. | (英) Glucose Tolerance Test (日) (読)
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| 9. | (英) Intra-Abdominal Fat (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Organ Specificity (日) (読)
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| 12. | (英) RNA (日) (読)
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| 13. | (英) Rats (日) (読)
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| 14. | (英) Rats, Inbred F344 (日) (読)
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| 15. | (英) Subcutaneous Fat (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)
| ○ISSN (任意): | □ | 0918-6158
ISSN: 0918-6158
(pISSN: 0918-6158, eISSN: 1347-5215) Title: Biological & pharmaceutical bulletinTitle(ISO): Biol Pharm BullSupplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
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| ○巻 (必須): | □ | 32
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 463 467
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 3月 初日 (平成 21年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/bpb.32.463 (→Scopusで検索)
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| ○PMID (任意): | □ | 19252296 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): | □ | 000263777800027
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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