『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.新田 剛
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2. (英) Murata Shigeo (日) (読)
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3.上野 智雄
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4. (英) Tanaka Keiji (日) (読)
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5.高浜 洋介
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題名 (必須): (英) Thymic microenvironments for T-cell repertoire formation.  (日)    [継承]
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要約 (任意): (英) Functionally competent immune system includes a functionally competent T-cell repertoire that is reactive to foreign antigens but is tolerant to self-antigens. The repertoire of T cells is primarily formed in the thymus through positive and negative selection of developing thymocytes. Immature thymocytes that undergo V(D)J recombination of T-cell antigen receptor (TCR) genes and that express the virgin repertoire of TCRs are generated in thymic cortex. The recent discovery of thymoproteasomes, a molecular complex specifically expressed in cortical thymic epithelial cells (cTEC), has revealed a unique role of cTEC in cuing the further development of immature thymocytes in thymic cortex, possibly by displaying unique self-peptides that induce positive selection. Cortical thymocytes that receive TCR-mediated positive selection signals are destined to survive for further differentiation and are induced to express CCR7, a chemokine receptor. Being attracted to CCR7 ligands expressed by medullary thymic epithelial cells (mTEC), CCR7-expressing positively selected thymocytes relocate to thymic medulla. The medullary microenvironment displays another set of unique self-peptides for trimming positively selected T-cell repertoire to establish self-tolerance, via promiscuous expression of tissue-specific antigens by mTEC and efficient antigen presentation by dendritic cells. Recent results demonstrate that tumor necrosis factor (TNF) superfamily ligands, including receptor activating NF-kappaB ligand (RANKL), CD40L, and lymphotoxin, are produced by positively selected thymocytes and pivotally regulate mTEC development and thymic medulla formation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoimmunity (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Clonal Deletion (日) (読) [継承]
5. (英) Dendritic Cells (日) (読) [継承]
6. (英) Epithelial Cells (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Receptors, Antigen, T-Cell (日) (読) [継承]
9. (英) Receptors, CCR7 (日) (読) [継承]
10. (英) Self Tolerance (日) (読) [継承]
11. (英) T-Lymphocyte Subsets (日) (読) [継承]
12. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Advances in Immunology ([Elsevier])
(pISSN: 0065-2776, eISSN: 1557-8445)

ISSN (任意): 0065-2776
ISSN: 0065-2776 (pISSN: 0065-2776, eISSN: 1557-8445)
Title: Advances in immunology
Title(ISO): Adv Immunol
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus (Scopus information is found. [need login])
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(必須): 99 [継承]
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(必須): 59 94 [継承]
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年月日 (必須): 西暦 2008年 0月 初日 (平成 20年 0月 初日) [継承]
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DOI (任意): 10.1016/S0065-2776(08)00603-2    (→Scopusで検索) [継承]
PMID (任意): 19117532    (→Scopusで検索) [継承]
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WOS (任意): 000262126600003 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 260  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Nitta, Shigeo Murata, Tomoo Ueno, Keiji Tanaka and Yousuke Takahama : Thymic microenvironments for T-cell repertoire formation., Advances in Immunology, Vol.99, (号), 59-94, 2008.
欧文冊子 ● Takeshi Nitta, Shigeo Murata, Tomoo Ueno, Keiji Tanaka and Yousuke Takahama : Thymic microenvironments for T-cell repertoire formation., Advances in Immunology, Vol.99, (号), 59-94, 2008.

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