『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=178841EID:178841, Map:0, LastModified:2017年12月4日(月) 14:08:17, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.医学部.医学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.病態予防医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1. (英) Soda Akira (日) 荘田 彰 (読) そうだ あきら
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2.池原 敏孝 ([徳島文理大学])
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3.木内 陽介
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4.吉﨑 和男
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題名 (必須): (英) Effects of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The effect of exposure to extremely low frequency-electromagnetic field (ELF-EMF: 3 mT, 60 Hz) on differentiation of mouse osteoblast-like MC3T3-E1 cells was examined together with addition of insulin-like growth factor I (IGF-I). As a marker of the differentiation, the cellular collagen content was determined by the absorbance of Sirius red-stained cells measured at the wavelength of 510-520 nm with an imaging microspectroscopy. Exposure to ELF-EMF increased significantly the collagen in the cells. Treatment with PD98059, an inhibitor of extracellular signal-regulated kinase 1/2 (ERK1/2) activation, reduced the collagen in all of the cells examined on control, IGF-I addition and ELF-EMF exposure, however, PD98059 did not prevent the increase in the collagen caused by ELF-EMF exposure, and IGF-I also increased the collagen in the presence of the inhibitor. When phosphatidylinositol 3-kinase (PI3K) pathway was inhibited by LY294002, the increase in collagen induced by ELF-EMF exposure was accelerated, however, the increase in collagen observed by IGF-I addition was suppressed. Treatment with SB203580, an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), suppressed the increase in the collagen induced by ELF-EMF exposure, whereas IGF-I addition increased the collagen in the presence of the inhibitor. These results suggested that collagen synthesis stimulated by ELF-EMF exposure was carried out by the participation of p38 MAPK pathway, and that PI3K pathway may have the role to suppress the collagen synthesis induced by ELF-EMF exposure, and that the suppression of the PI3K pathway may allow the acceleration of the collagen synthesis.  (日)    [継承]
キーワード (推奨): 1. (英) ELF-EMF (日) (読) [継承]
2. (英) ERK1/2 (日) (読) [継承]
3. (英) PI3K (日) (読) [継承]
4.コラーゲン [継承]
5.骨芽細胞 [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
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(必須): 3,4 [継承]
(必須): 267 278 [継承]
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年月日 (必須): 西暦 2008年 9月 初日 (平成 20年 9月 初日) [継承]
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DOI (任意): 10.2152/jmi.55.267    (→Scopusで検索) [継承]
PMID (任意): 18797142    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-56749174709 [継承]
機関リポジトリ (任意): 110870 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Physiology, Pathophysiological Preventive Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Akira Soda, Toshitaka Ikehara, Yohsuke Kinouchi and Kazuo Yoshizaki : Effects of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells., The Journal of Medical Investigation : JMI, Vol.55, No.3,4, 267-278, 2008.
欧文冊子 ● Akira Soda, Toshitaka Ikehara, Yohsuke Kinouchi and Kazuo Yoshizaki : Effects of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells., The Journal of Medical Investigation : JMI, Vol.55, No.3,4, 267-278, 2008.

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