| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hamazaki Yoko (日) (読)
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| 2. | (英) Fujita Harumi (日) (読)
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| 3. | (英) Kobayashi Takashi (日) (読)
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| 4. | (英) Choi Yongwon (日) (読)
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| 5. | (英) Scott S Hamish (日) (読)
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| 6. | 松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 7. | (英) Minato Nagahiro (日) (読)
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| ○題名 (必須): | □ | (英) Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin (日)
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| ○要約 (任意): | □ | (英) The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire(+) mTECs, however, are not well understood. Here we demonstrate that the tight-junction components claudin-3 and claudin-4 (Cld3,4) were 'preferentially' expressed in Aire(+) mTECs. In early ontogeny, Cld3,4(hi) TECs derived from the most apical layer of the stratified thymic anlage first expressed known mTEC markers such as UEA-1 ligand and MTS10. We provide evidence that such Cld3,4(hi) UEA-1(+) TECs represented the initial progenitors specified for Aire(+) mTECs, whose development crucially required NF-kappaB-inducing kinase and the adaptor molecule TRAF6. Our results suggest that Aire(+) mTECs represent terminally differentiated cells in a unique lineage arising during thymic organogenesis. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Differentiation (日) (読)
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| 3. | (英) Cell Lineage (日) (読)
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| 4. | (英) Embryo, Mammalian (日) (読)
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| 5. | (英) Epithelial Cells (日) (読)
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| 6. | (英) Flow Cytometry (日) (読)
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| 7. | (英) Histocompatibility Antigens Class II (日) (読)
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| 8. | (英) Immunohistochemistry (日) (読)
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| 9. | (英) Membrane Proteins (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 12. | (英) Thymus Gland (日) (読)
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| 13. | (英) Tight Junctions (日) (読)
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| 14. | (英) Transcription Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Immunology ([Nature Publishing Group])
(pISSN: 1529-2908, eISSN: 1529-2916)
| ○ISSN (任意): | □ | 1529-2908
ISSN: 1529-2908
(pISSN: 1529-2908, eISSN: 1529-2916) Title: Nature immunologyTitle(ISO): Nat ImmunolPublisher: Nature Publishing Group (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 304 311
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2007年 2月 4日 (平成 19年 2月 4日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/ni1438 (→Scopusで検索)
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| ○PMID (任意): | □ | 17277780 (→Scopusで検索)
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| ○評価値 (任意): | □ | ****
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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