『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=16915)

EID=16915EID:16915, Map:0, LastModified:2017年2月8日(水) 15:25:44, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.工学部.電気電子工学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.電気電子工学科.電気電子システム講座 [継承]
2.徳島大学.医学部 [継承]
著者 (必須): 1.池原 敏孝 ([徳島文理大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.朴 基豪 (University of Medicine and Dentistry of New Jersey)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.山口 久雄 ([徳島文理大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.細川 敬子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.吉﨑 和男
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.宮本 博司 ([徳島文理大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Aizawa Katsuo (日) 會沢 勝夫 (読) あいざわ かつお
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.木内 陽介
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Effects on Rb+(K+) Uptake of HeLa Cells in a High K+ Medium of Exposure to a Switched 1.7 Tesla Magnetic Field  (日)    [継承]
副題 (任意):
要約 (任意): (英) Effects of a switched, time-varying 1.7 T magnetic field on Rb(+)(K+) uptake by HeLa S3 cells incubated in an isosmotic high K(+) medium were examined. The magnetic flux density was varied intermittently from 0.07-1.7 T at an interval of 3 s. K(+) uptake was activated by replacement of normal medium by high K(+) medium. A membrane-permeable Ca(2+) chelating agent (BAPTA-AM) and Ca(2+)-dependent K(+) channel inhibitors (quinine, charibdotoxin, and iberiotoxin) were found to reduce the Rb(+)(K+) uptake by about 30-40%. Uptake of K(+) that is sensitive to these drugs is possibly mediated by Ca(2+)-dependent K(+) channels. The intermittent magnetic field partly suppress ed the drug-sensitive K(+) uptake by about 30-40% (P < 0.05). To test the mechanism of inhibition by the magnetic fields, intracellular Ca(2+) concentration ([Ca(2+)]c) was measured using Fura 2-AM. When cells were placed in the high K(&plus;) medium, [Ca(2+)]c increased to about 1.4 times the original level, but exposure to the magnetic fields completely suppressed the increase (P < 0.01). Addition of a Ca(2+) ionophore (ionomycin) to the high K(+) medium increased [Ca(2+)]c to the level of control cells, regardless of exposure to the magnetic field. But the inhibition of K(+) uptake by the magnetic fields was not restored by addition of ionomycin. Based on our previous results on magnetic field-induced changes in properties of the cell membrane, these results indicate that exposure to the magnetic fields partly suppresses K(+) influx, which may be mediated by Ca(2+)-dependent K(+) channels. The suppress ion of K(+) fluxes could relate to a change in electric properties of cell surface and an inhibition of Ca(2+) influx mediated by Ca(2+) channels of either the cell plasma membrane or the inner vesicular membrane of intracellular Ca(2+) stores.  (日)    [継承]
キーワード (推奨): 1.カルシウム (calcium) [継承]
2. (英) Cell Membrane (日) (読) [継承]
3. (英) Charybdotoxin (日) (読) [継承]
4. (英) Chelating Agents (日) (読) [継承]
5. (英) Culture Media (日) (読) [継承]
6. (英) Egtazic Acid (日) (読) [継承]
7. (英) Electromagnetic Fields (日) (読) [継承]
8.電気生理学 (electrophysiology) [継承]
9. (英) Environmental Exposure (日) (読) [継承]
10. (英) Fluorescent Dyes (日) (読) [継承]
11. (英) Fura-2 (日) (読) [継承]
12. (英) HeLa Cells (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14. (英) Intracellular Membranes (日) (読) [継承]
15. (英) Ionomycin (日) (読) [継承]
16. (英) Ionophores (日) (読) [継承]
17. (英) Magnetics (日) (読) [継承]
18. (英) Peptides (日) (読) [継承]
19.カリウム (potassium) [継承]
20. (英) Potassium Channel Blockers (日) (読) [継承]
21. (英) Potassium Channels (日) (読) [継承]
22. (英) Quinine (日) (読) [継承]
23. (英) Rubidium (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Bioelectromagnetics ([The Bioelectromagnetics Society])
(pISSN: 0197-8462, eISSN: 1521-186X)

ISSN (任意): 0197-8462
ISSN: 0197-8462 (pISSN: 0197-8462, eISSN: 1521-186X)
Title: Bioelectromagnetics
Title(ISO): Bioelectromagnetics
Supplier: Bioelectromagnetics Society
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 21 [継承]
(必須): 3 [継承]
(必須): 228 237 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 4月 10日 (平成 12年 4月 10日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 10723022    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Toshitaka Ikehara, Ki Ho Park, Hisao Yamaguchi, Keiko Hosokawa, Kazuo Yoshizaki, Hiroshi Miyamoto, Katsuo Aizawa and Yohsuke Kinouchi : Effects on Rb+(K+) Uptake of HeLa Cells in a High K+ Medium of Exposure to a Switched 1.7 Tesla Magnetic Field, Bioelectromagnetics, Vol.21, No.3, 228-237, 2000.
欧文冊子 ● Toshitaka Ikehara, Ki Ho Park, Hisao Yamaguchi, Keiko Hosokawa, Kazuo Yoshizaki, Hiroshi Miyamoto, Katsuo Aizawa and Yohsuke Kinouchi : Effects on Rb+(K+) Uptake of HeLa Cells in a High K+ Medium of Exposure to a Switched 1.7 Tesla Magnetic Field, Bioelectromagnetics, Vol.21, No.3, 228-237, 2000.

関連情報

Number of session users = 0, LA = 2.39, Max(EID) = 374169, Max(EOID) = 1002025.