『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=166267EID:166267, Map:0, LastModified:2014年2月27日(木) 15:31:42, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[松井 好人], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1. (英) Kubo Takahiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
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2.松井 好人
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3. (英) Goto Tomohiro (日) (読)
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4.油形 公則
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5.安井 夏生
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学籍番号 (推奨):
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題名 (必須): (英) Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene.  (日)    [継承]
副題 (任意):
要約 (任意): (英) In a subset of human lipomas, a specific t(3;12) chromosome translocation gives rise to HMGA2-LPP fusion protein, containing the amino (N)-terminal DNA binding domains of HMGA2 fused to the carboxyl (C)-terminal LIM domains of LPP. In addition to its role in adipogenesis, several observations suggest that HMGA2-LPP is linked to chondrogenesis. Here, we analyzed whether HMGA2-LPP promotes chondrogenic differentiation, a marker of which is transactivation of the alpha 2 type XI collagen gene (Col11a2). Real-time PCR analysis showed that HMGA2-LPP and COL11A2 were co-expressed. Luciferase assay demonstrated that either of HMGA2-LPP, wild-type HMGA2 or the N-terminal HMGA2 transactivated the Col11a2 promoter in HeLa cells, while the C-terminal LPP did not. RT-PCR analysis revealed that HMGA2-LPP transcripts in lipomas with the fusion were 591-fold of full-length HMGA2 transcripts in lipomas without the fusion. These results indicate that in vivo overexpression of HMGA2-LPP promotes chondrogenesis by upregulating cartilage-specific collagen gene expression through the N-terminal DNA binding domains.  (日)    [継承]
キーワード (推奨): 1. (英) Binding Sites (日) (読) [継承]
2. (英) Chondrogenesis (日) (読) [継承]
3. (英) Collagen Type XI (日) (読) [継承]
4. (英) Cytoskeletal Proteins (日) (読) [継承]
5. (英) DNA-Binding Proteins (日) (読) [継承]
6. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
7. (英) HMGA2 Protein (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) LIM Domain Proteins (日) (読) [継承]
10. (英) Lipoma (日) (読) [継承]
11. (英) Mutant Chimeric Proteins (日) (読) [継承]
12. (英) Promoter Regions, Genetic (日) (読) [継承]
13. (英) Protein Structure, Tertiary (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 340 [継承]
(必須): 2 [継承]
(必須): 476 481 [継承]
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年月日 (必須): 西暦 2006年 1月 1日 (平成 18年 1月 1日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbrc.2005.12.042    (→Scopusで検索) [継承]
PMID (任意): 16375854    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000234731800019 [継承]
Scopus (任意): 2-s2.0-29644438936 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takahiro Kubo, Yoshito Matsui, Tomohiro Goto, Kiminori Yukata and Natsuo Yasui : Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene., Biochemical and Biophysical Research Communications, Vol.340, No.2, 476-481, 2006.
欧文冊子 ● Takahiro Kubo, Yoshito Matsui, Tomohiro Goto, Kiminori Yukata and Natsuo Yasui : Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene., Biochemical and Biophysical Research Communications, Vol.340, No.2, 476-481, 2006.

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