『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=161578)

EID=161578EID:161578, Map:0, LastModified:2017年12月4日(月) 13:55:37, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.医学部.医学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 日本語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.山本 登志子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Prostaglandins in spinal cord : enzymological and histological study of prostaglandin F synthase  (日) 脊髄におけるプロスタグランジン   [継承]
副題 (任意):
要約 (任意): (英)   (日) In the spinal cord, prostaglandins participate in the pain transmission including hyperalgesiaand allodynia. Prostaglandin D2 and E2 induce hyperalgesia, while prostaglandin E2 and F2α induceallodynia. PGF2α synthase(PGFS)produce two stereoisomers of PGF2, PGF2α and9α, 11β-PGF2which are synthesized from PGH2 and PGD2, respectively, by the distinct reductions in theprostaglandin synthesis pathway. Because the two reduction are occurred in the different activesites, PGFS is a multifunctional enzyme. PGFS has at least two isozymes, namely, PGFSⅠ and Ⅱwith different Km values for PGD2(120 and 10μM, respectively). They belong to the aldo-ketoreductase superfamily based on substrate specificity, molecular weight, and amino acid sequence.In vivo, PGFSs possibly reduce some steroids such as dihydrotestosterone and dihydroprogesteroneby their enzymological characteristic. The morphological study of PGFSⅠ and Ⅱ in the rat spinalcord demonstrated their distinct localization. That is, PGFSⅠ existed in neuronal somata anddendrites, and PGFSⅡ existed in ependymal cells and tanycytes surrounding the central canal.Additionally, both PGFSⅠ and Ⅱ existed in endothelial cells of blood vessels. Furthermore, PGF2αreceptor, namely FP, was also present in neuronal somata and dendrites. Immunoreactivity forPGFSⅠ and FP was relatively intense in the dorsal horn of the spinal cord that is a connection siteof pain transmission. PGFSⅡ in the ependymal cells and tanycytes is not co-localized with FP, andmay mainly metabolize PGD2 which is one of the sleep inducers and abundant in the cerebrospinalfluid. These findings suggest that PGFSⅠ and Ⅱ in the rat spinal cord has different biologicalactions such as neuronal active receptivity and fluid component control, via different cell groups.   [継承]
キーワード (推奨): 1. (英) prostaglandin (日) (読) [継承]
2. (英) spinal cord (日) (読) [継承]
3. (英) PGFS 1 (日) (読) [継承]
4. (英) PGFS 2 (日) (読) [継承]
5. (英) allodynia (日) (読) [継承]
発行所 (推奨): (英) (日) 徳島医学会 (読) [継承]
誌名 (必須): 四国医学雑誌 ([徳島医学会])
(pISSN: 0037-3699)

ISSN (任意): 0037-3699
ISSN: 0037-3699 (pISSN: 0037-3699)
Title: 四国医学雑誌
Supplier: 徳島大学
Publisher: Tokushima Igakkai
 (Webcat Plus  (医中誌Web  (Scopus (Scopus information is found. [need login])
[継承]
[継承]
(必須): 61 [継承]
(必須): 1,2 [継承]
(必須): 25 30 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 4月 25日 (平成 17年 4月 25日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/40006794080/ [継承]
DOI (任意):
PMID (任意):
NAID (任意): 40006794080 [継承]
WOS (任意):
Scopus (任意):
機関リポジトリ : 45894 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意):

標準的な表示

和文冊子 ● 山本 登志子 : 脊髄におけるプロスタグランジン, 四国医学雑誌, Vol.61, No.1,2, 25-30, 2005年4月.
欧文冊子 ● Toshiko Suzuki-Yamamoto : Prostaglandins in spinal cord : enzymological and histological study of prostaglandin F synthase, Shikoku Acta Medica, Vol.61, No.1,2, 25-30, April 2005.

関連情報

Number of session users = 0, LA = 0.67, Max(EID) = 360369, Max(EOID) = 965174.