『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=159755)

EID=159755EID:159755, Map:0, LastModified:2014年2月18日(火) 15:54:49, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Obara Kumi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Ide Fumio (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Mishima Kenji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Inoue Hiroko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Yamada Hiroyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.林 良夫
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Saito Ichiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) To understand the salivary gland pathobiology, we established an immortalized duct/basal cell line (MSE) from the submandibular glands of p53-deficient mice. A variety of culture assays and xenograft experiments were conducted. Cellular characteristics were analyzed using histological, immunohistochemical, ultrastructural, and molecular techniques. Inoculation of a mixture of MSE and Matrigel reconstructed polarized ducts whereas cotransplantation of MSE with both Matrigel and NIH3T3 (3T3) cells developed mixed tumors of adenoma and sarcoma. A daughter adenoma line (MSA) showed some transformed phenotype in vitro, but was marginally tumorigenic in vivo. Notably, pleomorphic adenoma gene 1 (PLAG1) was expressed in MSA but not in MSE. As compared with MSE, MSA showed higher levels of insulin-like growth factor-I receptor (IGF-IR). Interestingly, 3T3 sarcoma secreted insulin-like growth factor-II (IGF-II), while MSA did not. The intrinsic tumorigenic programs of p53 null salivary epithelium are promoted by 3T3 sarcoma-derived IGF-IIin a paracrine manner through overexpression of PLAG1 and IGF-IR.  (日)    [継承]
キーワード (推奨): 1. (英) Adenoma, Pleomorphic (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blotting, Western (日) (読) [継承]
4. (英) Cell Communication (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Cell Transformation, Neoplastic (日) (読) [継承]
7.コラーゲン (collagen) [継承]
8. (英) DNA-Binding Proteins (日) (読) [継承]
9. (英) Drug Combinations (日) (読) [継承]
10. (英) Epithelial Cells (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12.免疫組織化学 (immunohistochemistry) [継承]
13. (英) Laminin (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Transgenic (日) (読) [継承]
16. (英) Microscopy, Electron, Transmission (日) (読) [継承]
17. (英) Neoplasms, Experimental (日) (読) [継承]
18. (英) Proteoglycans (日) (読) [継承]
19. (英) Receptor, IGF Type 1 (日) (読) [継承]
20. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
21. (英) Salivary Gland Neoplasms (日) (読) [継承]
22.唾液腺 (salivary glands/->キーワード[唾液腺]) [継承]
23. (英) Sarcoma (日) (読) [継承]
24. (英) Stromal Cells (日) (読) [継承]
25. (英) Tumor Suppressor Protein p53 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Pathobiology (S. Karger AG, Basel)
(pISSN: 1015-2008, eISSN: 1423-0291)

ISSN (任意): 1015-2008
ISSN: 1015-2008 (pISSN: 1015-2008, eISSN: 1423-0291)
Title: Pathobiology : journal of immunopathology, molecular and cellular biology
Title(ISO): Pathobiology
Publisher: S. Karger AG
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 73 [継承]
(必須): 5 [継承]
(必須): 261 270 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 0月 初日 (平成 18年 0月 初日) [継承]
URL (任意):
DOI (任意): 10.1159/000098212    (→Scopusで検索) [継承]
PMID (任意): 17314497    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000244516200006 [継承]
Scopus (任意): 2-s2.0-33847417897 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kumi Obara, Fumio Ide, Kenji Mishima, Hiroko Inoue, Hiroyuki Yamada, Yoshio Hayashi and Ichiro Saito : Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis., Pathobiology, Vol.73, No.5, 261-270, 2006.
欧文冊子 ● Kumi Obara, Fumio Ide, Kenji Mishima, Hiroko Inoue, Hiroyuki Yamada, Yoshio Hayashi and Ichiro Saito : Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis., Pathobiology, Vol.73, No.5, 261-270, 2006.

関連情報

Number of session users = 4, LA = 0.43, Max(EID) = 364767, Max(EOID) = 976858.