『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=146318)

EID=146318EID:146318, Map:0, LastModified:2017年12月4日(月) 14:06:51, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[楊河 宏章], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.矢野 聖二
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.楊河 宏章 ([徳島大学.病院.中央診療施設等.総合臨床研究センター])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.埴淵 昌毅
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Pai Kalpana (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Tsuruo Takashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.曽根 三郎
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) The role of cyclosporin A on antibody-dependent monocyte-mediated cytotoxicity against human multidrug-resistant cancer cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) A P-glycoprotein (P-gp) inhibitor, cyclosporin A (CsA) was found to enhance the susceptibility of multidrug resistant (MDR) cancer cells to anti-P-gp antibody-dependent cellular cytolysis (ADCC) by monocytes, but the exact mechanism is unknown. In this study, we examined whether CsA enhanced the susceptibility of MDR cells through its inhibitory effect of P-gp function by using anti-ganglioside GM2 (GM2) monoclonal antibody (Ab), KM966, instead of anti-P-gp Ab, MRK16. Monocyte-ADCC induced by both KM966 and MRK16 against P-gp positive human MDR ovarian cancer cells was significantly augmented by addition of CsA. KM966, but not MRK16, induced monocyte-ADCC against P-gp negative human ovarian cancer cells and CsA enhanced this ADCC activity, indicating that suppressive effect of P-gp function by CsA was not essential to the enhancement of ADCC. Moreover, pretreatment of tumor cells with CsA augmented their susceptibility to monocyte-ADCC irrespective of P-gp expression. Interestingly, KM966 or MRK16 induced monocyte-ADCC against various human lung cancer cells expressing either GM2 or P-gp, but CsA did not affect these ADCC. These findings suggest that CsA may enhance the susceptibility to the monocyte-ADCC of ovarian cancer cells, but not of lung cancer cells, irrespective of its suppressive effect of P-gp function.  (日)    [継承]
キーワード (推奨): 1. (英) Antibodies, Monoclonal (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Cyclosporine (日) (読) [継承]
4. (英) Cytotoxicity, Immunologic (日) (読) [継承]
5. (英) Drug Resistance, Multiple (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Monocytes (日) (読) [継承]
8. (英) Neoplasms (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 44 [継承]
(必須): 3-4 [継承]
(必須): 185 191 [継承]
都市 (任意):
年月日 (必須): 西暦 1998年 2月 初日 (平成 10年 2月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9597807&dopt=Abstract [継承]
DOI (任意):
PMID (任意): 9597807    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
機関リポジトリ : 110665 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Seiji Yano, Hiroaki Yanagawa, Masaki Hanibuchi, Kalpana Pai, Yasuhiko Nishioka, Takashi Tsuruo and Saburo Sone : The role of cyclosporin A on antibody-dependent monocyte-mediated cytotoxicity against human multidrug-resistant cancer cells, The Journal of Medical Investigation : JMI, Vol.44, No.3-4, 185-191, 1998.
欧文冊子 ● Seiji Yano, Hiroaki Yanagawa, Masaki Hanibuchi, Kalpana Pai, Yasuhiko Nishioka, Takashi Tsuruo and Saburo Sone : The role of cyclosporin A on antibody-dependent monocyte-mediated cytotoxicity against human multidrug-resistant cancer cells, The Journal of Medical Investigation : JMI, Vol.44, No.3-4, 185-191, 1998.

関連情報

Number of session users = 1, LA = 1.24, Max(EID) = 372548, Max(EOID) = 996414.