『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Parajuli Prahlad (日) (読)
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2.矢野 聖二
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3.埴淵 昌毅
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4. (英) Nokihara Hiroshi (日) (読)
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5.篠原 勉 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域呼吸器・総合内科学])
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6.曽根 三郎
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題名 (必須): (英) Effect of clarythromycin on the distant metastases of human lung cancer cells in SCID mice  (日)    [継承]
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要約 (任意): (英) Recently, the use of macrolides is suggested to be therapeutically effective in prolonging the survival of patients with inoperable non-small cell lung cancer. The purpose of this study was to examine therapeutic effects of a macrolide, clarythromycin (CAM) on the metastastic developments of two different human non-small cell lung cancers (squamous cell lung carcinoma RERF-LC-AI, and adenocarcinoma PC-14) in severe combined immunodeficient (SCID) mice depleted or undepleted of natural killer (NK) cells, respectively. CAM, injected subcutaneously at doses of 5 and 10 mg/kg body weight/day from day 7 to 41 after i.v. inoculation of human lung cancer cells, was not effective in inhibiting their distant organ metastases in SCID mice. CAM at concentrations of less than 10 micrograms/ml did not have a direct influence on the proliferation of these tumor cells in vitro. Although CAM alone was not effective in augmenting NK activity, it augmented the IL-2-induced killer (LAK) activity against Daudi cells in vitro. These results suggest that CAM alone may not be enough to control the spread of non-small cell lung cancer in the patient with T cell dysfunction.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Anti-Bacterial Agents (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Lung Neoplasms (日) (読) [継承]
5. (英) Macrolides (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, SCID (日) (読) [継承]
8. (英) Neoplasm Metastasis (日) (読) [継承]
9. (英) Neoplasm Transplantation (日) (読) [継承]
10. (英) Neoplasms, Experimental (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
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年月日 (必須): 西暦 1998年 2月 初日 (平成 10年 2月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9597810&dopt=Abstract [継承]
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PMID (任意): 9597810    (→Scopusで検索) [継承]
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機関リポジトリ : 110668 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Prahlad Parajuli, Seiji Yano, Masaki Hanibuchi, Hiroshi Nokihara, Tsutomu Shinohara and Saburo Sone : Effect of clarythromycin on the distant metastases of human lung cancer cells in SCID mice, The Journal of Medical Investigation : JMI, Vol.44, No.3-4, 205-210, 1998.
欧文冊子 ● Prahlad Parajuli, Seiji Yano, Masaki Hanibuchi, Hiroshi Nokihara, Tsutomu Shinohara and Saburo Sone : Effect of clarythromycin on the distant metastases of human lung cancer cells in SCID mice, The Journal of Medical Investigation : JMI, Vol.44, No.3-4, 205-210, 1998.

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