『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=146199EID:146199, Map:0, LastModified:2017年12月4日(月) 14:06:41, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[西岡 安彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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2. (英) Hua Wen (日) (読)
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3. (英) Nishimura Naoki (日) (読)
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4.曽根 三郎
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題名 (必須): (英) Genetic modification of dendritic cells and its application for cancer immunotherapy  (日)    [継承]
副題 (任意):
要約 (任意): (英) Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs). DCs pulsed with peptides of tumor-associated antigens (TAA) and tumor lysate have been used in cancer immunotherapy. An early clinical study demonstrated the safety of the use of DCs, but the clinical response was not sufficient. The gene-modification of DCs with TAA and soluble factor genes such as cytokine and chemokine genes has been examined to enhance the antigen-presenting capacity of DCs. Viral vectors including retroviruses and adenoviruses have been reported to be useful to obtain a sufficient transduction efficiency into DCs. TAA gene-transduced DCs could have several advantages compared with TAA peptide-pulsed DCs as follows: 1) The use of TAA gene-modified DCs are not restricted by MHC haplotypes. 2) The gene transduction with TAA genes is likely to present the unknown TAA peptides on DCs. 3) The gene-modified DCs show the prolonged presentation of TAA peptides. The transduction of DCs with cytokine genes including IL-12 and GM-CSF have also been reported to argument the antitumor effects of DCs. Although the results in the experimental systems were promising, the clinical application of gene-modified DCs includes several problems such as the standardization of methods of manipulation and gene-transduction of DCs. Approaches to solve them require further studies.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Dendritic Cells (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Immunotherapy, Adoptive (日) (読) [継承]
5. (英) Neoplasms (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 49 [継承]
(必須): 1,2 [継承]
(必須): 7 17 [継承]
都市 (任意): 徳島 (Tokushima/[日本国]) [継承]
年月日 (必須): 西暦 2002年 2月 初日 (平成 14年 2月 初日) [継承]
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PMID (任意): 11901764    (→Scopusで検索) [継承]
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機関リポジトリ : 110629 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Third Department of Internal Medicine, University of Tokushima School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
4.(英) NumberOfReferences: 87  (日)    [継承]

標準的な表示

和文冊子 ● Yasuhiko Nishioka, Wen Hua, Naoki Nishimura and Saburo Sone : Genetic modification of dendritic cells and its application for cancer immunotherapy, The Journal of Medical Investigation : JMI, Vol.49, No.1,2, 7-17, 2002.
欧文冊子 ● Yasuhiko Nishioka, Wen Hua, Naoki Nishimura and Saburo Sone : Genetic modification of dendritic cells and its application for cancer immunotherapy, The Journal of Medical Investigation : JMI, Vol.49, No.1,2, 7-17, 2002.

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