『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=145145)

EID=145145EID:145145, Map:0, LastModified:2017年11月29日(水) 17:45:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細井 和雄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1. (英) Murakami, Masataka (日) 村上 政隆 (読) むらかみ まさたか
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Murdiastuti, Kwartarini (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.細井 和雄
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Hill, E Adrian (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) AQP and the control of fluid transport in a salivary gland  (日)    [継承]
副題 (任意):
要約 (任意): (英) Experiments were performed with the perfused rat submandibular gland in vitro to investigate the nature of the coupling between transported salt and water by varying the osmolarity of the source bath and observing the changes in secretory volume flow. Glands were submitted to hypertonic step changes by changing the saline perfusate to one containing different levels of sucrose. The flow rate responded by falling to a lower value, establishing a new steady-state flow. The rate changes did not correspond to those expected from a system in which fluid production is due to simple osmotic equilibration, but were much larger. The changes were fitted to a model in which fluid production is largely paracellular, the rate of which is controlled by an osmosensor system in the basal membrane. The same experiments were done with glands from rats that had been bred to have very low levels of AQP5 (the principal aquaporin of the salivary acinar cell) in which little AQP5 is expressed at the basal membrane. In these rats, salivary secretion rates after hypertonic challenges were small and best modelled by simple osmotic equilibration. In rats which had intermediate AQP5 levels the changes in flow rate were similar to those of normal rats although their AQP5 levels were reduced.Finally, perfused normal glands were subject to retrograde ductal injection of salines containing different levels of Hg(2+) ions (0, 10 and 100 microM: ) which would act as inhibitors of AQP5 at the apical acinar membrane. The overall flow rates were progressively diminished with rising Hg(2+) concentration, but after hypertonic challenge the changes in flow rates were unchanged and similar to those of normal rats. All these results are difficult to explain by a cellular osmotic model but can be explained by a model in which paracellular flow is controlled by an osmosensor (presumably AQP5) present on the basal membrane.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Aquaporin 5 (日) (読) [継承]
3. (英) Biological Transport (日) (読) [継承]
4. (英) Cell Membrane Permeability (日) (読) [継承]
5. (英) Mercury (日) (読) [継承]
6. (英) Models, Biological (日) (読) [継承]
7. (英) Organ Culture Techniques (日) (読) [継承]
8. (英) Osmolar Concentration (日) (読) [継承]
9. (英) Perfusion (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11. (英) Rats, Sprague-Dawley (日) (読) [継承]
12. (英) Salivation (日) (読) [継承]
13. (英) Submandibular Gland (日) (読) [継承]
発行所 (推奨): (英) Springer New York (日) (読) [継承]
誌名 (必須): The Journal of Membrane Biology ([Springer-Verlag])
(pISSN: 0022-2631, eISSN: 1432-1424)

ISSN (任意): 0022-2631
ISSN: 0022-2631 (pISSN: 0022-2631, eISSN: 1432-1424)
Title: The Journal of membrane biology
Title(ISO): J Membr Biol
Supplier: Springer Online Journal Archive
Publisher: Springer New York
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 210 [継承]
(必須): 2 [継承]
(必須): 91 103 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 3月 初日 (平成 18年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s00232-005-0848-2    (→Scopusで検索) [継承]
PMID (任意): 16868676    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000239818500003 [継承]
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Center for Integrative Bioscience, NIPS, National Institute for Natural Sciences, Myoudaiji, Okazaki 444-8787, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Masataka Murakami, Kwartarini Murdiastuti, Kazuo Hosoi and Adrian E Hill : AQP and the control of fluid transport in a salivary gland, The Journal of Membrane Biology, Vol.210, No.2, 91-103, 2006.
欧文冊子 ● Masataka Murakami, Kwartarini Murdiastuti, Kazuo Hosoi and Adrian E Hill : AQP and the control of fluid transport in a salivary gland, The Journal of Membrane Biology, Vol.210, No.2, 91-103, 2006.

関連情報

Number of session users = 0, LA = 3.01, Max(EID) = 382164, Max(EOID) = 1020881.