『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○著者 (必須): 1. (英) Chowdhury Mohammed Golam Mowla (日) (読)
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2.前田 健一
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3.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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4.前川 洋一
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5. (英) Furukawa Atsuko (日) (読)
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6. (英) Azuma Miyuki (日) (読)
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7. (英) Nagasawa Hideyuki (日) (読)
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8. (英) Himeno Kunisuke (日) (読)
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○題名 (必須): □(英) Antigen-specific B cells are required for the secondary response of T cells but not for their priming  (日)    [継承]
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○要約 (任意): □(英) We studied the potential role of B cells in T cell responses using severe-combined immunodeficient (SCID) mice grafted with the thymus from fetal C.B-17 mice (TG mice). These mice developed both CD4+ and CD8+ T cells, but not B cells within 2 months after transplantation. TG mice showed normal delayed-type hypersensitivity responses against the immunizing antigen ovalbumin (OVA). Lymph node (LN) cells of TG mice proliferated well in response to concanavalin A (Con A). Further, Con A stimulation induced the production of interleukin (IL)-2, IL-6 and interferon (IFN)-gamma and the expression of IL-4 mRNA. Thus, TG mice were reconstituted without remarkable immunodeficiency. However, these T cells failed to proliferate to OVA stimulation. Response to OVA was also inhibited in SCID mice grafted with fetal C.B-17 liver cells when B cells were depleted in the proliferation assay. Unresponsiveness against immunizing antigen was restored by the addition of antigen-primed B cells, but not by naive B cells, lipopolysaccharide-activated B cells or B cells primed with sheep red blood cells. Next, we examined whether antigen-primed B cells could induce T cell responses without professional antigen-presenting cells (APC). T and B cells were purified from OVA-immunized mice by cell sorter. These T cells proliferated in response to OVA and produced IFN-gamma in the absence of non-B APC. When anti-CD80 or anti-CD86 was added in the assay, proliferation and IFN-gamma production was inhibited. These results indicate that B cells activated specifically with antigen are required for the secondary response of T cells, but not for their priming.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigen-Presenting Cells (日) (読) [継承]
3. (英) Antigens, CD28 (日) (読) [継承]
4. (英) Antigens, CD80 (日) (読) [継承]
5. (英) B-Lymphocytes (日) (読) [継承]
6. (英) Epitopes (日) (読) [継承]
7. (英) Fetal Tissue Transplantation (日) (読) [継承]
8.造血 (hematopoiesis) [継承]
9. (英) Hypersensitivity, Delayed (日) (読) [継承]
10. (英) Immunization, Secondary (日) (読) [継承]
11. (英) Liver Transplantation (日) (読) [継承]
12. (英) Lymphocyte Activation (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, SCID (日) (読) [継承]
15. (英) Ovalbumin (日) (読) [継承]
16.Tリンパ球 (T lymphocytes) [継承]
17. (英) Thymus Gland (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)

○ISSN (任意): □0014-2980
ISSN: 0014-2980 (pISSN: 0014-2980, eISSN: 1521-4141)
Title: European journal of immunology
Title(ISO): Eur J Immunol
Supplier: European Federation of Immunological Societies
Publisher: Wiley
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○巻 (必須): □26 [継承]
○号 (必須): □7 [継承]
○頁 (必須): □1628 1633 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1996年 7月 初日 (平成 8年 7月 初日) [継承]
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○DOI (任意): □10.1002/eji.1830260733    (→Scopusで検索) [継承]
○PMID (任意): □8766571    (→Scopusで検索) [継承]
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○Scopus (任意): □2-s2.0-0029947638 [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Mowla Mohammed Golam Chowdhury, Kenichi Maeda, Koji Yasutomo, Yoichi Maekawa, Atsuko Furukawa, Miyuki Azuma, Hideyuki Nagasawa and Kunisuke Himeno : Antigen-specific B cells are required for the secondary response of T cells but not for their priming, European Journal of Immunology, Vol.26, No.7, 1628-1633, 1996.
欧文冊子 ● Mowla Mohammed Golam Chowdhury, Kenichi Maeda, Koji Yasutomo, Yoichi Maekawa, Atsuko Furukawa, Miyuki Azuma, Hideyuki Nagasawa and Kunisuke Himeno : Antigen-specific B cells are required for the secondary response of T cells but not for their priming, European Journal of Immunology, Vol.26, No.7, 1628-1633, 1996.

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