| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Chowdhury Mohammed Golam Mowla (日) (読)
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| 2. | (英) Furukawa Atsuko (日) (読)
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| 3. | 香川 征
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| 4. | 前田 健一
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| 5. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 6. | (英) Himeno Kunisuke (日) (読)
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| ○題名 (必須): | □ | (英) B cells are required as APC for antigen-specific T cell proliferation but not the differentiation or priming of those T cells (日)
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| ○要約 (任意): | □ | (英) We studied the influences of B cells on functional differentiation of T cells using SCID mice grafted with fetal thymus of C.B-17 mice (TG mice). T cells were shown to be reconstituted in TG mice without B cell development. These mice showed normal DTH response to SRBC and OVA. LN cells of these mice produced cytokines including IL-2, IL-4, IL-6 and IFN-gamma according to Con A stimulation. Thus, majority of T cell functions seem to differentiate in the absence of B cells. However, T cells of TG mice failed to proliferate in response to immunizing antigens in vitro, although they responded well to stimulation with Con A. This unresponsiveness of T cells in TG mice to these antigens was restored when antigen-primed B cells were added to the proliferation assay. Such an inability of T cells in antigen-specific proliferation was not seen in SCID mice grafted with C.B-17 fetal liver cells, in which B cells as well as T cells were efficiently reconstituted (FLT mice). T cell proliferation to immunizing antigen was also abrogated in FLT mice when B cells were depleted from lymphoid population. These results indicate that T cells can functionally differentiate and be primed in the absence of B cells, but they require B cells to proliferate in response to foreign antigens. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigen-Presenting Cells (日) (読)
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| 3. | (英) B-Lymphocytes (日) (読)
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| 4. | 細胞分化 (cell differentiation)
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| 5. | 細胞分裂 (cell division)
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| 6. | (英) Concanavalin A (日) (読)
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| 7. | (英) Epitopes (日) (読)
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| 8. | (英) Immunization (日) (読)
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| 9. | (英) Lymphocyte Activation (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Mice, SCID (日) (読)
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| 12. | Tリンパ球 (T lymphocytes)
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| 13. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Tokushima Journal of Experimental Medicine ([徳島大学.医学部])
(pISSN: 0040-8875)
| ○ISSN (任意): | □ | 0040-8875
ISSN: 0040-8875
(pISSN: 0040-8875) Title: The Tokushima journal of experimental medicineTitle(ISO): Tokushima J Exp MedSupplier: 徳島大学Publisher: Tokushima University School of Medicine (NLM Catalog)
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| ○巻 (必須): | □ | 41
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| ○号 (必須): | □ | 1-2
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| ○頁 (必須): | □ | 1 8
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1994年 6月 初日 (平成 6年 6月 初日)
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| ○URL (任意): |
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| ○PMID (任意): | □ | 7524190 (→Scopusで検索)
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| ○CRID (任意): |
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| ○Scopus (任意): | □ | 2-s2.0-0028452350
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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