『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1. (英) Manabe Kazuyoshi (日) (読)
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2.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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3.岸 潤
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4. (英) Inayama Mami (日) (読)
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5.青野 純典 ([呼吸器・膠原病内科学])
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6. (英) Nakamura Yoichi (日) (読)
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7. (英) Ogushi Fumitaka (日) (読)
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8. (英) Bando Hiroyasu (日) (読)
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9.谷 憲治 ([徳島大学.病院.中央診療施設等.総合診療部]/[徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).総合診療医学])
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10.曽根 三郎
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題名 (必須): (英) Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages  (日)    [継承]
副題 (任意):
要約 (任意): (英) Macrophage-derived chemokine (MDC/CCL22) and thymus-and activation-regulated chemokine (TARC/CCL17) are ligands for CC chemokine receptor 4. Recently, TARC has been reported to play a role in the pathogenesis of idiopathic eosinophilic pneumonia (IEP). The purpose of this study was to evaluate the role of MDC in IEP and other interstitial lung diseases (ILDs). MDC and TARC in the bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay in patients with ILDs and healthy volunteers (HV). We also examined the expression of MDC mRNA in alveolar macrophages (AM) by real-time quantitative reverse transcriptase-polymerase chain reaction. Both MDC and TARC were detected only in BALF obtained from IEP patients. The concentration of MDC was higher than that of TARC in all cases. The level of MDC in IEP correlated with that of TARC. AM from IEP patients expressed a significantly higher amount of MDC than that from HV at the levels of protein and mRNA. MDC in BALF from IEP dramatically decreased when patients achieved remission. These findings suggest that MDC, in addition to TARC, might be involved in the pathogenesis of IEP, and AM play a role in the elevation of MDC in IEP.  (日)    [継承]
キーワード (推奨): 1. (英) bronchoalveolar lavage fluid (日) (読) [継承]
2. (英) macrophage-derived chemokine (日) (読) [継承]
3. (英) thymus-and activation-regulated chemokine (日) (読) [継承]
4. (英) eosinophilic pneumonia (日) (読) [継承]
5. (英) alveolar macrophages (日) (読) [継承]
6. (英) interstitial lung diseases (日) (読) [継承]
発行所 (推奨): (英) The University of Tokushima (日) 徳島大学 (読) [継承]
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 85 92 [継承]
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年月日 (必須): 西暦 2005年 2月 初日 (平成 17年 2月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/110002261665/ [継承]
DOI (任意): 10.2152/jmi.52.85    (→Scopusで検索) [継承]
PMID (任意): 15751278    (→Scopusで検索) [継承]
NAID (任意): 110002261665 [継承]
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機関リポジトリ : 110761 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuyoshi Manabe, Yasuhiko Nishioka, Jun Kishi, Mami Inayama, Yoshinori Aono, Yoichi Nakamura, Fumitaka Ogushi, Hiroyasu Bando, Kenji Tani and Saburo Sone : Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages, The Journal of Medical Investigation : JMI, Vol.52, No.1,2, 85-92, 2005.
欧文冊子 ● Kazuyoshi Manabe, Yasuhiko Nishioka, Jun Kishi, Mami Inayama, Yoshinori Aono, Yoichi Nakamura, Fumitaka Ogushi, Hiroyasu Bando, Kenji Tani and Saburo Sone : Elevation of macrophage-derived chemokine in eosinophilic pneumonia: a role of alveolar macrophages, The Journal of Medical Investigation : JMI, Vol.52, No.1,2, 85-92, 2005.

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