『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=130856)

EID=130856EID:130856, Map:0, LastModified:2013年12月10日(火) 10:47:15, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[香美 祥二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1.香美 祥二 ([徳島大学.病院])
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2.近藤 秀治 ([徳島大学.病院.中央診療施設等.地域小児科診療部])
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3. (英) Klemens Loster (日) (読)
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[継承]
4. (英) Reutter Werner (日) (読)
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5.漆原 真樹 ([徳島大学.病院.診療科.小児·周産·女性科.小児科])
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6.北村 明子 ([徳島大学.病院.先端医療開発研究プロジェクト]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
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7. (英) Kobayashi Shoko (日) (読)
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8.黒田 𣳾弘
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題名 (必須): (英) Collagen Type I Modulates the Platelet-Derived Growth Factor (PDGF) Regulation of the Growth and Expression of β1 Integrins by Rat Mesangial Cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mesangial cell (MC) proliferation and the deposition of collagen type I (collagen I) are the major pathological features in many types of glomerulonephritis (GN). Recent work suggested that beta-integrins play a critical role in the cell proliferation and extracellular matrix (ECM) remodeling observed in tissue repair after injury. To examine the involvement of beta-integrins in MC proliferation in association with the interaction of MCs with pathological collagen I, we investigated the effect of a prominent mitogen, platelet-derived growth factor-BB (PDGF-BB) on the growth and expression of beta-integrins by MCs cultured on plastic or in a three-dimensional collagen I gel. Immunoprecipitation using 35S-metabolic labeling, flow cytometry and a 3H-thymidine-uptake analysis demonstrated that PDGF-BB stimulated the cell mitogenicity and the expression of alpha5beta1 integrin (a fibronectin receptor), but not alpha1beta1 integrin (a collagen and laminin receptor) of MCs on plastic, in a dose-dependent manner. In contrast, MCs in the collagen I gels showed no significant changes in mitogenicity or alpha1beta1 and alpha5beta1 integrin expression, but increased alpha1beta1 integrin-mediated gel contraction was observed after PDGF-BB stimulation. Thus, the parallel up-regulation of MC-mitogenicity and alpha5beta1 integrin expression by PDGF-BB suggested that alpha5beta1 integrin is an important ECM receptor involved in the proliferative phenotype of MC. A spatial interaction between MCs and pathological collagen I in GN may influence the PDGF regulation of the MC phenotype regarding the cell growth and the expression of beta1 integrins.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD29 (日) (読) [継承]
3.細胞分裂 (cell division) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5.コラーゲン (collagen) [継承]
6. (英) Glomerular Mesangium (日) (読) [継承]
7. (英) Platelet-Derived Growth Factor (日) (読) [継承]
8. (英) Proto-Oncogene Proteins c-sis (日) (読) [継承]
9. (英) Rats (日) (読) [継承]
10. (英) Rats, Sprague-Dawley (日) (読) [継承]
発行所 (推奨): Academic Press (->組織[Elsevier Science]) [継承]
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem. Biophys. Res. Commun.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 252 [継承]
(必須): 3 [継承]
(必須): 728 732 [継承]
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年月日 (必須): 西暦 1998年 11月 27日 (平成 10年 11月 27日) [継承]
URL (任意): http://dx.doi.org/10.1006/bbrc.1998.9733 [継承]
DOI (任意): 10.1006/bbrc.1998.9733    (→Scopusで検索) [継承]
PMID (任意): 9837774    (→Scopusで検索) [継承]
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WOS (任意): 000077339700034 [継承]
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備考 (任意): 1.(英) Article.Affiliation: School of Medicine, University of Tokushima, Tokushima, 770-0042, Japan. kagami@medclin.clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shoji Kagami, Shuji Kondo, Loster Klemens, Werner Reutter, Maki Urushihara, Akiko Kitamura, Shoko Kobayashi and Yasuhiro Kuroda : Collagen Type I Modulates the Platelet-Derived Growth Factor (PDGF) Regulation of the Growth and Expression of β1 Integrins by Rat Mesangial Cells, Biochemical and Biophysical Research Communications, Vol.252, No.3, 728-732, 1998.
欧文冊子 ● Shoji Kagami, Shuji Kondo, Loster Klemens, Werner Reutter, Maki Urushihara, Akiko Kitamura, Shoko Kobayashi and Yasuhiro Kuroda : Collagen Type I Modulates the Platelet-Derived Growth Factor (PDGF) Regulation of the Growth and Expression of β1 Integrins by Rat Mesangial Cells, Biochemical and Biophysical Research Communications, Vol.252, No.3, 728-732, 1998.

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