『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=130377)

EID=130377EID:130377, Map:0, LastModified:2013年11月7日(木) 15:02:20, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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2. (英) Kinouchi Takemi (日) (読) きのうち たけみ
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3.片岡 佳子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
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学籍番号 (推奨):
[継承]
4.桑原 知巳
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5.大西 克成
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題名 (必須): (英) Effect of Intestinal Bacteria on Formation of Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon  (日)    [継承]
副題 (任意):
要約 (任意): (英) The effect of intestinal bacteria on formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) and DNA adducts in the rat colon was investigated. Male Sprague-Dawley rats were administered cultures of Lactobacillus acidophilus, Bifidobacterium adolescentis, Bacteroides fragilis, Escherichia coli and Clostridium perfringens for five weeks and given injections of AOM at 15 mg/kg body weight at the first and second weeks. The number of ACF five weeks after the start of the experiment was decreased in the rats treated with the cultures or culture supernatants of L. acidophilus and C. perfringens. The half-life of O6-methylguanine (O6-meG) in the L. acidophilus group was shorter than that in the GAM broth group. The half-life of 7-methylguanine did not differ among the groups. These results suggest that the metabolite(s) of L. acidophilus and C. perfringens inhibit(s) the ACF formation in rats treated with AOM and that the inhibitory effect of L. acidophilus is due to the enhanced removal of O6-meG from the colon mucosal DNA.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Azoxymethane (日) (読) [継承]
3. (英) Bacteroides fragilis (日) (読) [継承]
4. (英) Bifidobacterium (日) (読) [継承]
5. (英) Body Weight (日) (読) [継承]
6. (英) Clostridium perfringens (日) (読) [継承]
7. (英) Colonic Neoplasms (日) (読) [継承]
8. (英) Culture Media (日) (読) [継承]
9. (英) Drinking (日) (読) [継承]
10. (英) Escherichia coli (日) (読) [継承]
11. (英) Guanine (日) (読) [継承]
12. (英) Injections, Subcutaneous (日) (読) [継承]
13. (英) Intestinal Mucosa (日) (読) [継承]
14. (英) Lactobacillus acidophilus (日) (読) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Rats, Sprague-Dawley (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 238 [継承]
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(必須): 753 757 [継承]
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年月日 (必須): 西暦 1997年 9月 29日 (平成 9年 9月 29日) [継承]
URL (任意): http://dx.doi.org/10.1006/bbrc.1997.7384 [継承]
DOI (任意): 10.1006/bbrc.1997.7384    (→Scopusで検索) [継承]
PMID (任意): 9325162    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Bacteriology, School of Medicine, The University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hideki Arimochi, Takemi Kinouchi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi : Effect of Intestinal Bacteria on Formation of Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon, Biochemical and Biophysical Research Communications, Vol.238, No.3, 753-757, 1997.
欧文冊子 ● Hideki Arimochi, Takemi Kinouchi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi : Effect of Intestinal Bacteria on Formation of Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon, Biochemical and Biophysical Research Communications, Vol.238, No.3, 753-757, 1997.

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