| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Sakai Tohru (日) (読)
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| 2. | (英) Agui Takashi (日) (読)
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| 3. | (英) Yamada Takahisa (日) (読)
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| 4. | 松本 耕三
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| ○題名 (必須): | □ | (英) Inheritance of Immunoglobulin Subclass Regulator-1 (Igsr-1) in LEC Mutant Rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Long-Evans Cinnamon (LEC) mutant rats were reported to exhibit a deficiency in the serum immunoglobulin (Ig) G1. The phenotype determining the basal level of IgG1 was tentatively designated as immunoglobulin subclass regulator-1 (Igsr-1), and normal rats and LEC rats were categorized into Igsr-1A (normal expression of IgG1) and Igsr-1B (low expression of IgG1), respectively. In this report we examined genetic trait of this phenotype in LEC rats. The serum IgG1 levels in F1 hybrids produced by mating LEC rats (Igsr-1B) with normal rats (Igsr-1A) were intermediate level, indicating that Igsr-1 behaves as a co-dominant genetic trait. When backcross rats were examined, serum IgG1 levels varied between those in normal and LEC rats without clear segregation, indicating that Igsr-1 is controlled by multiple genes. Furthermore, the serum IgG1 level in each backcross rat did not correlate to another recessive mutant genotype, thid (T-helper immunodeficiency). These data suggest that the deficiency in serum IgG in LEC rats is independent of the deficiency in helper T cell function, but might be due to the multiple deficiency in as-yet-unidentified mechanisms. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 3. | (英) Crosses, Genetic (日) (読)
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| 4. | (英) Enzyme-Linked Immunosorbent Assay (日) (読)
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| 5. | (英) Female (日) (読)
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| 6. | (英) Flow Cytometry (日) (読)
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| 7. | (英) Immunoglobulin G (日) (読)
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| 8. | (英) Immunologic Deficiency Syndromes (日) (読)
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| 9. | (英) Male (日) (読)
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| 10. | (英) Phenotype (日) (読)
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| 11. | (英) Rats (日) (読)
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| 12. | (英) Rats, Mutant Strains (日) (読)
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| 13. | (英) Reference Values (日) (読)
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| 14. | (英) T-Lymphocytes, Helper-Inducer (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Veterinary Medical Science ([社団法人 日本獣医学会])
(pISSN: 0916-7250, eISSN: 1347-7439)
| ○ISSN (任意): | □ | 0916-7250
ISSN: 0916-7250
(pISSN: 0916-7250, eISSN: 1347-7439) Title: The Journal of veterinary medical scienceTitle(ISO): J Vet Med SciSupplier: 社団法人日本獣医学会Publisher: Japanese Society of Veterinary Science (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 56
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 883 886
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1994年 10月 初日 (平成 6年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1292/jvms.56.883 (→Scopusで検索)
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| ○PMID (任意): | □ | 7865588 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0028525397
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) GeneSymbolList.GeneSymbol: Igrs-1 (日)
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| 4. | (英) GeneSymbolList.GeneSymbol: thid (日)
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