| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Sakai T (日) (読)
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| 2. | (英) Agui T (日) (読)
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| 3. | 松本 耕三
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| ○題名 (必須): | □ | (英) Expression of major histocompatibility complex class II but not of CD8 molecules by lectin-stimulated peripheral CD4+ T cells in LEC mutant rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) LEC rats show a congenital maturational arrest from CD4+8+ to CD4+8- but not to CD4-8+ cells in the thymus. However, some CD4+ cells exist in peripheral lymph nodes. In normal F344 rats, a part of CD4+ T cells expressed CD8 molecules upon concanavaline A (Con A) stimulation. The percentage of CD4+8+ cells and the level of CD8 expression in F344 rat CD4+ cells were enhanced by the glucocorticoid hormone dexamethasone. In contrast, although LEC rat CD4+ cells induced DNA synthesis normally upon Con A stimulation, expression of CD8 was significantly reduced. Furthermore, addition of dexamethasone did not restore the inhibition of CD8 expression. However, LEC rat CD4+ cells could induce CD8 expression, when stimulated by T cell receptor (TCR) cross-linking with anti-TCR monoclonal antibody, suggesting that the TCR-mediated signal is normally transduced in LEC rat CD4+ cells. On the other hand, LEC rat CD4+ cells showed normal expression of major histocompatibility complex (MHC) class II antigens, when stimulated by either Con A or TCR cross-linking, indicating that signals for the induction of MHC class II expression are normal in LEC rat CD4+ cells. Activation of peripheral CD4+ cells has been reported to induce simultaneous expression of CD8 and MHC class II molecules in rats. However, our results using LEC rat CD4+ cells suggest that Con A-induced signaling pathways for CD8 and MHC class II expression can be separable. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD8 (日) (読)
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| 3. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 4. | (英) Cells, Cultured (日) (読)
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| 5. | (英) Concanavalin A (日) (読)
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| 6. | (英) DNA Replication (日) (読)
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| 7. | (英) Dexamethasone (日) (読)
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| 8. | (英) Flow Cytometry (日) (読)
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| 9. | (英) Histocompatibility Antigens Class II (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Rats, Inbred F344 (日) (読)
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| 12. | (英) Rats, Mutant Strains (日) (読)
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| 13. | (英) Receptors, Antigen, T-Cell (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cellular Immunology ([Elsevier])
(pISSN: 0008-8749, eISSN: 1090-2163)
| ○ISSN (任意): | □ | 0008-8749
ISSN: 0008-8749
(pISSN: 0008-8749, eISSN: 1090-2163) Title: Cellular immunologyTitle(ISO): Cell ImmunolPublisher: Academic Press Inc. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 158
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 414 422
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1994年 10月 初日 (平成 6年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1006/cimm.1994.1287 (→Scopusで検索)
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| ○PMID (任意): | □ | 7923392 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0027939474
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Institute for Animal Experimentation, University of Tokushima School of Medicine, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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