| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
| [継承] |
| ○著者 (必須): | 1. | (英) Sakai Tohru (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Agui Takashi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Muramatsu Yoji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Nagasawa Hideyuki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Himeno Kunisuke (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 松本 耕三
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Low level of immunoglobulin G2a subclass correlates with a deficiency in T helper cell function in LEC mutant rats. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Long-Evans Cinnamon (LEC) rats bear a congenital deficiency in CD4+8- thymocytes and consequently a deficiency in helper T cell function. This mutation is caused by a single recessive gene referred to as thid (T helper immunodeficiency). It has been reported that rat immunoglobulin(Ig) G2a subclass is a counterpart of the mouse IgG1. Serum IgG2a levels in LEC rats were ten-fold lower than those of normal rats. To identify a cause of low IgG2a levels in LEC rats, we made backcross rats, (F344 x LEC)F1 x LEC, and examined linkage to the thid mutation. The serum IgG2a levels of rats showing thid/thid phenotype were much lower than those of rats showing +/thid phenotype. This indicates that the thid mutation correlates with low level of IgG2a subclass. Furthermore, LEC rat B cells were shown to secret IgG2a normally when these were stimulated with LPS and IL-4, suggesting that a cause of low level of IgG2a was due to defect of T cell function but not due to B cell disfunction in LEC rats. These results confirm the idea that T-helper (Th) function is necessary for the class switch to IgG2a subclass in rats. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Antibodies, Monoclonal (日) (読)
| [継承] |
| 3. | (英) B-Lymphocytes (日) (読)
| [継承] |
| 4. | (英) CD4 Antigens (日) (読)
| [継承] |
| 5. | (英) CD8 Antigens (日) (読)
| [継承] |
| 6. | (英) Crosses, Genetic (日) (読)
| [継承] |
| 7. | (英) Enzyme-Linked Immunosorbent Assay (日) (読)
| [継承] |
| 8. | (英) Genes, Recessive (日) (読)
| [継承] |
| 9. | (英) Genetic Linkage (日) (読)
| [継承] |
| 10. | (英) Immunoglobulin G (日) (読)
| [継承] |
| 11. | (英) Immunologic Deficiency Syndromes (日) (読)
| [継承] |
| 12. | (英) Mice (日) (読)
| [継承] |
| 13. | (英) Phenotype (日) (読)
| [継承] |
| 14. | (英) Rats (日) (読)
| [継承] |
| 15. | (英) Rats, Inbred F344 (日) (読)
| [継承] |
| 16. | (英) Rats, Mutant Strains (日) (読)
| [継承] |
| 17. | (英) Reference Values (日) (読)
| [継承] |
| 18. | (英) T-Lymphocytes, Helper-Inducer (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Veterinary Medical Science ([社団法人 日本獣医学会])
(pISSN: 0916-7250, eISSN: 1347-7439)
| ○ISSN (任意): | □ | 0916-7250
ISSN: 0916-7250
(pISSN: 0916-7250, eISSN: 1347-7439) Title: The Journal of veterinary medical scienceTitle(ISO): J Vet Med SciSupplier: 社団法人日本獣医学会Publisher: Japanese Society of Veterinary Science (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 57
| [継承] |
| ○号 (必須): | □ | 3
| [継承] |
| ○頁 (必須): | □ | 517 529
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1995年 6月 初日 (平成 7年 6月 初日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1292/jvms.57.527 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 7548412 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0029318089
| [継承] |
| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |