『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨): □Peer Review [継承]
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨): 1.徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門]) [継承]
○著者 (必須): 1. (英) Cai Yiqiang (日) (読)
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○学籍番号 (推奨):
[継承]
2. (英) Xin Xiaonan (日) (読)
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○学籍番号 (推奨):
[継承]
3. (英) Shim Gil-Jin (日) (読)
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○学籍番号 (推奨):
[継承]
4. (英) Mokuno Yoko (日) (読)
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5. (英) Uehara Hisanori (日) (読)
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6. (英) Yaamda Takahisa (日) (読)
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7. (英) Agui Takashi (日) (読)
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○学籍番号 (推奨):
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8.松本 耕三
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○題名 (必須): □(英) Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) stimulate interleukin-6 production the third subtype of PACAP/VIP receptor in rat bone marrow-derived stromal cells.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Regulation of Interleukin-6 (IL-6) production in bone marrow (BM)-derived stromal cells by neuropeptides, pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP), was examined. Both forms of PACAP, PACAP-27 and PACAP-38, as well as VIP significantly increased IL-6 production by rat BM-derived stromal cells at physiological concentrations ranging from 10(-10)-10(-8) M. The three related peptides (PACAP-27, -38, and VIP) stimulated the production of both cAMP and inositol 1,4,5-trisphosphate (IP3) in rat BM-derived stromal cells with similar 50% effective concentrations. The stimulatory potency of the three related peptides for the production of IL-6, cAMP, and IP3 was almost consistent, suggesting that the dual signaling transduction pathways may be involved in PACAP/VIP-induced IL-6 production in rat BM-derived stromal cells. The messenger RNA (mRNA) for the third subtype of PACAP receptor (PVR3) was found to be abundantly expressed in both BM-derived stromal cells and the BM tissue, whereas little of the mRNA for type 1 (PVR1) nor type 2 (PVR2) was detected. Furthermore, the mRNAs for PACAP and VIP were detected in the BM tissue, suggesting that both PACAP/VIP and PVR3 are synthesized in vivo in the BM. The results shown in this paper suggest that PACAP/VIP and their receptor play an important role in the IL-6 production and perhaps in the hematopoiesis in the BM.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bone Marrow (日) (読) [継承]
3. (英) Bone Marrow Cells (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Cyclic AMP (日) (読) [継承]
6. (英) DNA Primers (日) (読) [継承]
7. (英) Inositol 1,4,5-Trisphosphate (日) (読) [継承]
8. (英) Interleukin-6 (日) (読) [継承]
9. (英) Kinetics (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Neuropeptides (日) (読) [継承]
12. (英) Neurotransmitter Agents (日) (読) [継承]
13. (英) Pituitary Adenylate Cyclase-Activating Polypeptide (日) (読) [継承]
14. (英) Polymerase Chain Reaction (日) (読) [継承]
15. (英) RNA, Messenger (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Rats, Inbred F344 (日) (読) [継承]
18. (英) Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide (日) (読) [継承]
19. (英) Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I (日) (読) [継承]
20. (英) Receptors, Pituitary Hormone (日) (読) [継承]
21. (英) Receptors, Vasoactive Intestinal Peptide (日) (読) [継承]
22. (英) Stromal Cells (日) (読) [継承]
23. (英) Transcription, Genetic (日) (読) [継承]
24. (英) Vasoactive Intestinal Peptide (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Endocrinology (Association for the Study of Internal Secretions (US)/[The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

○ISSN (任意): □0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Oxford University Press
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □138 [継承]
○号 (必須): □6 [継承]
○頁 (必須): □2515 2520 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1997年 6月 初日 (平成 9年 6月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1210/endo.138.6.5169    (→Scopusで検索) [継承]
○PMID (任意): □9165043    (→Scopusで検索) [継承]
○CRID (任意):
○Scopus (任意): 1.2-s2.0-0030962179 [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yiqiang Cai, Xiaonan Xin, Gil-Jin Shim, Yoko Mokuno, Hisanori Uehara, Takahisa Yaamda, Takashi Agui and Kozo Matsumoto : Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) stimulate interleukin-6 production the third subtype of PACAP/VIP receptor in rat bone marrow-derived stromal cells., Endocrinology, 138, 6, 2515-2520, 1997.
欧文冊子 ● Yiqiang Cai, Xiaonan Xin, Gil-Jin Shim, Yoko Mokuno, Hisanori Uehara, Takahisa Yaamda, Takashi Agui and Kozo Matsumoto : Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) stimulate interleukin-6 production the third subtype of PACAP/VIP receptor in rat bone marrow-derived stromal cells., Endocrinology, 138, 6, 2515-2520, 1997.

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