『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨): □Peer Review [継承]
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨): 1.徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門]) [継承]
○著者 (必須): 1. (英) Sakai T (日) (読)
○役割 (任意):
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○学籍番号 (推奨):
[継承]
2. (英) Agui T (日) (読)
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○学籍番号 (推奨):
[継承]
3. (英) Wei K (日) (読)
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○学籍番号 (推奨):
[継承]
4. (英) Ika M (日) (読)
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○学籍番号 (推奨):
[継承]
5. (英) Hisaeda H (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
6. (英) Nagasawa H (日) (読)
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○学籍番号 (推奨):
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7. (英) Himeno K (日) (読)
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○学籍番号 (推奨):
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8.松本 耕三
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○題名 (必須): □(英) Unresponsiveness of CD4-thymocytes to lectin stimulation in LEC mutant rats.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) A mutant strain of rat, LEC, shows a novel arrest of T-cell maturation from CD4+8+ to CD4+8-, but not to CD4-8+ cells in the thymus. The responsible mutant locus is designated the thid, which was acted upon in a recessive manner of inheritance. We found that LEC rat thymocytes failed to respond to interleukin (IL)-1, IL-6 and IL-7 in the presence of the mitogenic lectins, Allo A or concanavalin A (Con A). The unresponsiveness appeared to be due to unresponsiveness to the lectin stimulation rather than because of cytokine stimulation. Normal rat CD4-8+/- (consisting of CD4-8+ and CD4-8- thymocytes), CD4+/-8- (consisting of CD4+8- and CD4-8- thymocytes), and CD4-8- thymocyte subsets normally responded to mitogenic stimulation, while CD4+8+ thymocytes did not. In contrast, all LEC rat CD4-8+/-, CD4+/-8-, CD4-8- and CD4-8+ thymocytes did not respond to the mitogenic stimulation, suggesting that the unresponsiveness of the CD4-8+/- thymocytes seems to be responsible for the unresponsiveness of whole thymocytes in LEC rats. LEC rat CD4-8+/- thymocytes normally expressed Con A receptor (R), lymphocyte function-associated antigen-1 (LFA-1), and CD45, which are thought to be important molecules for lectin stimulation. When backcross rats from (F344xLEC)F1xLEC were examined, the phenotype for the thid mutation correlated with the [3H]thymidine deoxyribose (TdR) incorporation level in response to Con A stimulation; thymocytes from backcross rats showing +/thid phenotype responded to Con A stimulation normally, whereas thymocytes from backcross rats showing thid/thid phenotype showed significantly lower responsiveness compared with +/thid rats. However, in WKAH.C-thid congenic rat thymocytes that carry the thid mutation, the responsiveness to mitogenic stimulation was comparable to that of normal rat thymocytes. These results suggest that a defect in responsiveness to mitogenic stimulation in LEC rat thymocytes is controlled by multiple genetic loci and the thid locus is one of the important loci for the development of this abnormal phenotype.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Animals, Congenic (日) (読) [継承]
3. (英) Antigens, Differentiation, T-Lymphocyte (日) (読) [継承]
4. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
5. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
6. (英) Cell Differentiation (日) (読) [継承]
7. (英) Concanavalin A (日) (読) [継承]
8. (英) Flow Cytometry (日) (読) [継承]
9. (英) Galectins (日) (読) [継承]
10. (英) Gene Deletion (日) (読) [継承]
11. (英) Genes (日) (読) [継承]
12. (英) Genetic Linkage (日) (読) [継承]
13. (英) Hemagglutinins (日) (読) [継承]
14. (英) Hybridomas (日) (読) [継承]
15. (英) Lectins (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Rats, Inbred F344 (日) (読) [継承]
18. (英) Rats, Inbred LEC (日) (読) [継承]
19. (英) Specific Pathogen-Free Organisms (日) (読) [継承]
20. (英) Stimulation, Chemical (日) (読) [継承]
21. (英) T-Lymphocytes, Helper-Inducer (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)

○ISSN (任意): □0019-2805
ISSN: 0019-2805 (pISSN: 0019-2805, eISSN: 1365-2567)
Title: Immunology
Title(ISO): Immunology
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog)   (Wiley)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □95 [継承]
○号 (必須): □2 [継承]
○頁 (必須): □219 225 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1998年 10月 初日 (平成 10年 10月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1046/j.1365-2567.1998.00574.x    (→Scopusで検索) [継承]
○PMID (任意): □9824479    (→Scopusで検索) [継承]
○CRID (任意):
○Scopus (任意): 1.2-s2.0-0031721616 [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● T Sakai, T Agui, K Wei, M Ika, H Hisaeda, H Nagasawa, K Himeno and Kozo Matsumoto : Unresponsiveness of CD4-thymocytes to lectin stimulation in LEC mutant rats., Immunology, 95, 2, 219-225, 1998.
欧文冊子 ● T Sakai, T Agui, K Wei, M Ika, H Hisaeda, H Nagasawa, K Himeno and Kozo Matsumoto : Unresponsiveness of CD4-thymocytes to lectin stimulation in LEC mutant rats., Immunology, 95, 2, 219-225, 1998.

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