『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=113515)

EID=113515EID:113515, Map:0, LastModified:2025年9月2日(火) 15:15:24, Operator:[山下 圭子], Avail:TRUE, Censor:承認済, Owner:[[学科長]/[徳島大学.医学部.医学科]], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨): □Peer Review [継承]
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨): 1.徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門]) [継承]
○著者 (必須): 1. (英) Yamada T (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
2. (英) Sogawa K (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
3. (英) Kim JK (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
4. (英) Izumi K (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
5. (英) Muramatsu Y (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
6. (英) Sumida T (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
7. (英) Hamakawa H (日) (読)
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
8.松本 耕三
○役割 (任意):
○貢献度 (任意):
○学籍番号 (推奨):
[継承]
○題名 (必須): □(英) Increased polyploidy, delayed mitosis and reduced protein phosphatase-1 activity associated with excess copper in the Long Evans Cinnamon rat.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Until now, it is not known whether copper hepatotoxicity impairs mitosis. Enlarged hepatocytes with huge nuclei considered as polyploids are frequently observed in the Long Evans Cinnamon (LEC) rat which exhibits an abnormal accumulation of hepatic copper due to a defect in the gene homologous to human Wilson's disease gene responsible for intracellular copper delivery. This defect may lead to a abnormal mitotic progression in increased polyploidization and is associated with excessive hepatic copper. This study was designed to examine whether excess copper impairs mitotic progression and results in increased polyploidization using a model of LEC rat liver. Polyploidy was analyzed by flow cytometry. The rate of mitotic progression was investigated using the fraction of mitotic hepatocytes or a mitosis-specific phosphoprotein retained in regeneration. Nuclear protein phosphatase-1 (PP-1) activity essential to mitotic progression was measured. The effect of excess copper on incidence of polyploidy, the rate of mitotic progression and nuclear PP-1 activity was investigated using age- or copper overload-dependent changes in them in LEC rat, or genetic profile-dependent changes of them in backcrosses. LEC rat liver showed an increase of polyploidy, a delay of mitotic progression, and a reduction of nuclear PP-1 activity. These abnormal features concurred with increase of copper concentration accompanied by changes of age in LEC rats from 2 to 4 months of age, induced by dietary copper overload in LEC rat, or caused by single genetic defect in backcrosses. Excess copper impairs mitotic progression, resulting in increased polyploidization. Nuclear PP-1 activity is likely to be at least one of targets of copper hepatotoxicity leading to impairment of mitotic progression.  (日)    [継承]
○キーワード (推奨): 1. (英) Age Factors (日) (読) [継承]
2. (英) Animal Nutritional Physiological Phenomena (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Cell Nucleus (日) (読) [継承]
5. (英) Copper (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Liver (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mitosis (日) (読) [継承]
10. (英) Phosphoprotein Phosphatases (日) (読) [継承]
11. (英) Polyploidy (日) (読) [継承]
12. (英) Protein Phosphatase 1 (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Inbred F344 (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Research Communications in Molecular Pathology and Pharmacology (Webstbury)
(pISSN: 1078-0297)

○ISSN (任意): □1078-0297
ISSN: 1078-0297 (pISSN: 1078-0297)
Title: Research communications in molecular pathology and pharmacology
Title(ISO): Res Commun Mol Pathol Pharmacol
Publisher: PJD Publications Ltd
 (NLM Catalog)   (Scopus)  (Scopus information is found. [need login])
[継承]
[継承]
○巻 (必須): □99 [継承]
○号 (必須): □3 [継承]
○頁 (必須): □283 304 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1998年 3月 初日 (平成 10年 3月 初日) [継承]
○URL (任意):
○DOI (任意):
○PMID (任意): □9591324    (→Scopusで検索) [継承]
○CRID (任意):
○Scopus (任意): 1.2-s2.0-0031946338 [継承]
○researchmap (任意):
○評価値 (任意):
○被引用数 (任意):
○指導教員 (推奨):
○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T Yamada, K Sogawa, JK Kim, K Izumi, Y Muramatsu, T Sumida, H Hamakawa and Kozo Matsumoto : Increased polyploidy, delayed mitosis and reduced protein phosphatase-1 activity associated with excess copper in the Long Evans Cinnamon rat., Research Communications in Molecular Pathology and Pharmacology, 99, 3, 283-304, 1998.
欧文冊子 ● T Yamada, K Sogawa, JK Kim, K Izumi, Y Muramatsu, T Sumida, H Hamakawa and Kozo Matsumoto : Increased polyploidy, delayed mitosis and reduced protein phosphatase-1 activity associated with excess copper in the Long Evans Cinnamon rat., Research Communications in Molecular Pathology and Pharmacology, 99, 3, 283-304, 1998.

関連情報

Number of session users = 0, LA = 2.08, Max(EID) = 458829, Max(EOID) = 1219637.