| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Ogino T (日) (読)
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| 2. | (英) Moralejo DH (日) (読)
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| 3. | (英) Zhu M (日) (読)
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| 4. | (英) Toide K (日) (読)
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| 5. | (英) Wei S (日) (読)
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| 6. | (英) Wei K (日) (読)
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| ○貢献度 (任意): |
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| 7. | (英) Yamada T (日) (読)
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| 8. | (英) Mizuno A (日) (読)
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| 9. | 松本 耕三
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| ○題名 (必須): | □ | (英) Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat exhibits sustained hyperglycaemia after partial pancreatectomy, while the normal control rat does not. This difference is thought to be genetically determined and to be caused by impairment of beta-cell regrowth, a possible event involved in the pathogenesis of NIDDM. Our investigation was designed to identify quantitative trait loci (QTL) responsible for post-pancreatectomy hyperglycaemia by performing a genome-wide scan in an F2 intercross obtained by mating the OLETF and Fischer-344 (F344) rats. We have identified three possible QTL on rat chromosomes (Chrs) 3, 14 and 19 that account for a total of approximately 75% of the genetic variance in the F2. For the QTL on Chr 14, the OLETF allele corresponds with increased glucose levels, as expected. Surprisingly, for the QTL on Chr 19, the F344 allele corresponds with increased glucose levels. The Chr 3 QTL exhibits heterosis, heterozygotes showing significantly higher glucose levels than OLETF or F344 homozygotes. We also found evidence for interaction (epistasis) between the QTL on Chrs 14 and 19. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Chromosome Mapping (日) (読)
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| 3. | (英) Diabetes Mellitus, Type 2 (日) (読)
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| 4. | (英) Female (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Hyperglycemia (日) (読)
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| 7. | (英) Male (日) (読)
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| 8. | (英) Pancreatectomy (日) (読)
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| 9. | (英) Quantitative Trait, Heritable (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Rats, Inbred F344 (日) (読)
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| 12. | (英) Rats, Mutant Strains (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Genetical Research ([Cambridge University Press])
(pISSN: 0016-6723, eISSN: 1469-5073)
| ○ISSN (任意): | □ | 0016-6723
ISSN: 0016-6723
(pISSN: 0016-6723, eISSN: 1469-5073) Title: Genetics researchTitle(ISO): Genet Res (Camb)Publisher: Cambridge University Press (NLM Catalog)
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| ○巻 (必須): | □ | 73
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 29 36
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1999年 2月 初日 (平成 11年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1017/S0016672398003644 (→Scopusで検索)
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| ○PMID (任意): | □ | 10218444 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Institute for Animal Experimentation, University of Tokushima School of Medicine, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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