| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Masaki Tsutomu (日) (読)
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| 2. | (英) Tokuda Masaaki (日) (読)
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| 3. | (英) Shiratori Yasushi (日) (読)
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| 4. | (英) Shirai Mutsunori (日) (読)
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| 5. | 松本 耕三
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| 6. | (英) Nishioka Mikio (日) (読)
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| 7. | (英) Omata Masao (日) (読)
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| ○題名 (必須): | □ | (英) A possible novel src-related tyrosine kinase in cancer cells of LEC rats that develop hepatocellular carcinoma. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Src-related protein tyrosine kinase is known to be related to cell transformation. In this study, we report a possible novel src-related tyrosine kinase of 100 kDa specifically expressed in the nuclei of hepatocytes and/or cancer cells in Long-Evans Cinnamon rats, one of the experimental models of hepatocellular carcinoma. Src-related protein tyrosine kinase in hepatocytes of Long-Evans Cinnamon rats was analyzed by using immunohistochemistry and Western blot and in vitro tyrosine kinase assay using a specific antibody (src antibody) against a synthetic peptide corresponding to the conserved autophosphorylation site of src family tyrosine kinases. Src-related protein was found to be expressed in the nuclei of hepatocytes and/or cancer cells in Long-Evans Cinnamon rat liver, exhibiting tyrosine kinase activity, and migrated to the position of 100 kDa. The protein quantity and activity of this 100-kDa src-related protein tyrosine kinase significantly increased with the progress of chronic hepatitis to hepatocellular carcinoma, especially in the tumorous portion of the liver. On the other hand, the 100-kDa src-protein tyrosine kinase was not observed in the nuclei of hepatocytes and/or cancer cells in normal age-matched control Wistar rats. Since the src-family tyrosine kinases have been observed at a molecular weight of 55 to 62 kDa and located in the hepatocellular membrane and/or cytoplasm, the 100-kDa src-related protein tyrosine kinase observed in the present study may be novel, and closely related to the pre-cancerous and cancerous process in Long-Evans Cinnamon rat liver. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blotting, Western (日) (読)
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| 3. | (英) Carcinoma, Hepatocellular (日) (読)
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| 4. | (英) Cell Fractionation (日) (読)
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| 5. | (英) Cell Nucleus (日) (読)
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| 6. | (英) Immunoenzyme Techniques (日) (読)
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| 7. | (英) Liver (日) (読)
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| 8. | (英) Liver Neoplasms, Experimental (日) (読)
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| 9. | (英) Rats (日) (読)
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| 10. | (英) Rats, Inbred LEC (日) (読)
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| 11. | (英) Rats, Wistar (日) (読)
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| 12. | (英) Specific Pathogen-Free Organisms (日) (読)
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| 13. | (英) src-Family Kinases (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Hepatology (European Association for the Study of the Liver)
(pISSN: 0168-8278, eISSN: 1600-0641)
| ○ISSN (任意): | □ | 0168-8278
ISSN: 0168-8278
(pISSN: 0168-8278, eISSN: 1600-0641) Title: Journal of hepatologyTitle(ISO): J HepatolPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 32
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 92 99
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2000年 1月 初日 (平成 12年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 10673072 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0033985302
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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