| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Masaki Tsutomu (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Shiratori Yasushi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Rengifo William (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Igarashi Kouichi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 松本 耕三
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Nishioka Mikio (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Hatanaka Yoshio (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Omata Masao (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Hepatocellular carcinoma cell cycle: Study of Long-Evans Cinnamon rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Amplification found in a number of cyclin genes, especially in cyclin D and E, is an important event process that takes place in cancers, including hepatocellular carcinoma (HCC). The activities of a wide range of cell cycle-related kinases remain obscure in HCC. The purpose of the present study is to determine the cyclins and kinase activities of HCC in Long-Evans Cinnamon (LEC) rats. Cyclin D1, E, A, H, Cdk1(cyclin-dependent kinase; Cdc2), Cdk4, and Cdk6 protein levels were determined by Western blot analysis at different pathologic stages of liver tissues exhibiting HCC. Enzymatic activities of cyclin D1, E, A, Cdk4, Cdk6, Cdc2, Cdk7, and Wee1 kinase were measured by in-gel kinase assay. Protein levels and kinase activities of cyclin D1, E, Cdk4, cyclin A, and Wee1 increased proportionally with the development of HCC, especially in the transition process from chronic hepatitis to HCC. Although Cdc2 kinase activity was found to increase slightly from normal liver to chronic hepatitis, its activity remained unchanged in the process from chronic hepatitis to HCC. Cdk6 and Cdk7 activities remained unchanged in the process from normal liver to HCC. These data suggest that the increase in Cdc2 kinase may play a role in the process from normal liver to chronic hepatitis, whereas the predominant increase in cyclin D1, Cdk4, cyclin E, cyclin A, and Wee1 suggests involvement not only in the process from normal liver to chronic hepatitis, but also during transition into HCC. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blotting, Western (日) (読)
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| 3. | (英) Cell Cycle (日) (読)
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| 4. | (英) Cell Cycle Proteins (日) (読)
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| 5. | (英) Cyclin A (日) (読)
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| 6. | (英) Cyclin D1 (日) (読)
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| 7. | (英) Cyclin E (日) (読)
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| 8. | (英) Cyclin-Dependent Kinases (日) (読)
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| 9. | (英) Cyclins (日) (読)
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| 10. | (英) Liver Neoplasms, Experimental (日) (読)
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| 11. | (英) Rats (日) (読)
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| 12. | (英) Rats, Long-Evans (日) (読)
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| 13. | (英) Rats, Wistar (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Hepatology (American Association for the Study of Liver Diseases)
(pISSN: 0270-9139, eISSN: 1527-3350)
| ○ISSN (任意): | □ | 0270-9139
ISSN: 0270-9139
(pISSN: 0270-9139, eISSN: 1527-3350) Title: Hepatology (Baltimore, Md.)Title(ISO): HepatologySupplier: American Association for the Study of Liver DiseasesPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 32
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 711 720
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2000年 10月 初日 (平成 12年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1053/jhep.2000.17705 (→Scopusで検索)
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| ○PMID (任意): | □ | 11003614 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0033803787
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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