| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hayashi Yuki (日) (読)
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| 2. | 石丸 直澄
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| 3. | 新垣 理恵子
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| 4. | 九十九 伸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 5. | 福井 仁美 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.分子口腔医学講座.口腔分子病態学])
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| 6. | 岸原 健二
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| 7. | 塩田 洋
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| 8. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 9. | 林 良夫
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| ○題名 (必須): | □ | (英) Effective Treatment of a Mouse Model of Sjogren's Syndrome With Eyedrop Administrasiton of Anti-CD4 Monoclonal Antibody (日)
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| ○要約 (任意): | □ | (英) To determine whether eyedrop administration of an anti-CD4 monoclonal antibody (mAb) is effective in the treatment of Sjögren's syndrome (SS) using a mouse model of the disease. The anti-CD4 mAb was administered daily into the eyes of mice with SS from ages 4 to 8 weeks or ages 10 to 12 weeks. During treatment, tear volume was monitored and after final treatment, histologic features of the lacrimal and salivary glands, the phenotypes and function of T cells, and serum titers of anti-alpha-fodrin antibody were examined. Eyedrop administration of anti-CD4 mAb before the onset of SS prevented the autoimmune pathology seen in the lacrimal glands but not that in the salivary glands. Furthermore, eyedrop administration of anti-CD4 mAb after the development of SS inhibited mononuclear cell infiltration and the destruction of parenchyma only in the lacrimal glands. Eyedrop administration of anti-CD4 mAb suppressed the local activation of CD4+ T cells rather than deleting CD4+ T cells, which reduced the expansion of pathologic CD4+ T cells against alpha-fodrin. These results demonstrate the remarkable efficacy of anti-CD4 mAb eyedrops in the treatment of SS eye symptoms, which illustrates a new antibody-based therapeutic strategy for patients with eye problems caused by SS as well as other diseases. (日)
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| ○キーワード (推奨): | 1. | (英) Administration, Topical (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Antibodies, Monoclonal (日) (読)
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| 4. | (英) Antigens, CD4 (日) (読)
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| 5. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 6. | (英) Disease Progression (日) (読)
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| 7. | (英) Dry Eye Syndromes (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Lacrimal Apparatus (日) (読)
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| 10. | (英) Lymphocyte Activation (日) (読)
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| 11. | (英) Mice (日) (読)
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| 12. | (英) Models, Animal (日) (読)
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| 13. | (英) Ophthalmic Solutions (日) (読)
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| 14. | 唾液腺 (salivary glands/->キーワード[唾液腺])
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| 15. | シェーグレン症候群 (Sjögren's syndrome)
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| 16. | (英) Treatment Outcome (日) (読)
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| ○発行所 (推奨): | □ | (英) American College of Rheumatology (日) (読)
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| ○誌名 (必須): | □ | Arthritis and Rheumatism (American Rheumatism Association/Arthritis Foundation/American Rheumatism Association/American College of Rheumatology)
(pISSN: 0004-3591, eISSN: 1529-0131)
| ○ISSN (任意): | □ | 0004-3591
ISSN: 0004-3591
(pISSN: 0004-3591, eISSN: 1529-0131) Title: Arthritis and rheumatismTitle(ISO): Arthritis RheumPublisher: John Wiley & Sons Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 50
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 2903 2910
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| ○年月日 (必須): | □ | 西暦 2004年 9月 初日 (平成 16年 9月 初日)
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| ○URL (任意): | □ | http://www3.interscience.wiley.com/cgi-bin/abstract/109609639/ABSTRACT
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| ○DOI (任意): | □ | 10.1002/art.20472 (→Scopusで検索)
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| ○PMID (任意): | □ | 15457459 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: The University of Tokushima School of Medicine, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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