| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.医学科.病態予防医学講座
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| ○著者 (必須): | 1. | 前川 洋一
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| 2. | 九十九 伸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 3. | (英) Hiroko Okada (日) (読)
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| 4. | 岸原 健二
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| 5. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) Breakdown of peripheral T-cell tolerance by chronic IL-15 elevation (日)
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| ○要約 (任意): | □ | (英) Thymic deletion purges the repertoire of most developing T cells with the potential for overt self-reactivity, but some self-specific cells do emerge into the peripheral pool. Under most conditions, these potentially autoaggressive cells remain in a quiescent state. However, in some circumstances, they become activated and acquire effector function, leading to immune disease. It is thus important to clarify the mechanism(s) responsible for determining the balance between such inappropriate T-cell activation and the normal state of peripheral tolerance. In this article, we show that chronic elevation of interleukin-15 levels interferes with the tolerant state of CD8+ T cells through a process that involves activation of nonlymphoid antigen-presenting cells by CD4+asialo-GM1+ (ASGM1) or both CD4+ASGM1- and CD4-ASGM1+ cells. These findings suggest a potential role for dysregulated interleukin-15 production in promoting tolerance breakdown. This new information may be of potential use in improving tumor vaccines to self-antigens and in ameliorating autoimmune or graft-versus-host disease. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 3. | (英) CD8-Positive T-Lymphocytes (日) (読)
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| 4. | (英) Fetal Tissue Transplantation (日) (読)
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| 5. | (英) Graft vs Host Disease (日) (読)
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| 6. | (英) Hematopoietic Stem Cell Transplantation (日) (読)
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| 7. | (英) Immune Tolerance (日) (読)
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| 8. | (英) Interleukin-15 (日) (読)
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| 9. | (英) Liver (日) (読)
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| 10. | (英) Lymphocyte Activation (日) (読)
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| 11. | (英) Mice (日) (読)
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| 12. | (英) Mice, Inbred AKR (日) (読)
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| 13. | (英) Mice, SCID (日) (読)
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| 14. | (英) Spleen (日) (読)
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| 15. | (英) Thymus Gland (日) (読)
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| 16. | (英) Transplantation Chimera (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Transplantation (The Transplantation Society)
(pISSN: 0041-1337, eISSN: 1534-6080)
| ○ISSN (任意): | □ | 0041-1337
ISSN: 0041-1337
(pISSN: 0041-1337, eISSN: 1534-6080) Title: TransplantationTitle(ISO): TransplantationPublisher: Lippincott Williams and Wilkins (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 76
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 415 420
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 7月 27日 (平成 15年 7月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/01.TP.0000078900.71840.2B (→Scopusで検索)
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| ○PMID (任意): | □ | 12883202 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000184445400025
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Immunology and Parasitology, School of Medicine, University of Tokushima, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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