『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=100697)

EID=100697EID:100697, Map:0, LastModified:2013年9月11日(水) 20:33:54, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[石川 康子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
2.徳島大学.歯学部.歯学科 [継承]
著者 (必須): 1. (英) Amano Ichiro (日) 天野 伊知郎 (読) あまの いちろう
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2.石川 康子
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3. (英) Ishida Hajie (日) 石田 甫 (読) いしだ はじめ
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題名 (必須): (英) Regulation of phosphorylation of Gi2αprotein controls the secretory response to isoproterenol in rat parotid tissues.  (日)    [継承]
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要約 (任意): (英) Treatment of rat parotid tissues with 1 microM isoproterenol (IPR) for 10 min caused a 60% decrease in pertussis toxin (IAP)-catalyzed ADP-ribosylation of Gi alpha and resulted in supersensitivity of amylase secretion from the tissues. However, conversely, IPR treatment for 30 min caused a 40% increase in IAP-catalyzed ADP-ribosylation of Gi alpha, coupled with desensitization of amylase secretion. No changes in Gs function were observed in IPR-induced phenomena. Pretreatment with okadaic acid induced enhancement of the supersensitivity of amylase secretion and disappearance of the desensitization. These phenomena were accompanied with decreases in IAP-catalyzed ADP-ribosylation of Gi alpha. IPR treatment for 30 min caused a 50% decrease in phosphorylation of Gi2 alpha immunoprecipitated with anti-G protein antiserum (AS/7) from [32P]Pi-labeled cells, but such treatment for 10 min caused a 40% increase in phosphorylation in the cells pretreated with okadaic acid. Phosphorylation and dephosphorylation of immunoprecipitates with AS/7 by protein kinase A (PKA) and alkaline phosphatase caused decreases and increases in IAP-catalyzed ADP-ribosylation, respectively, indicating the presence of PKA-mediated phosphorylation sites on Gi2 alpha. Thus, the control of the phosphorylation of Gi2 alpha is of importance and relevance in the regulation of biological processes and cellular responses.  (日)    [継承]
キーワード (推奨): 1.顎口腔機能 (stomatognathic function) [継承]
2.情報伝達機構 (signal transduction) [継承]
3.神経伝達物質 (neurotransmitter) [継承]
4. (英) Phosphorylation (日) りん酸化 (読) りんさんか [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ([Elsevier Science])
(pISSN: 0167-4889)

ISSN (任意): 0167-4889
ISSN: 0167-4889 (pISSN: 0167-4889, eISSN: 1879-2596)
Title: Biochimica et biophysica acta. Molecular cell research
Title(ISO): Biochim Biophys Acta Mol Cell Res
Publisher: Elsevier BV
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(必須): 146 156 [継承]
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年月日 (必須): 西暦 1996年 8月 28日 (平成 8年 8月 28日) [継承]
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DOI (任意): 10.1016/0167-4889(96)00060-2    (→Scopusで検索) [継承]
PMID (任意): 8781562    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Biochimica et Biophysica Acta (BBA) - Molecular Cell Research  (日)    [継承]

標準的な表示

和文冊子 ● Ichiro Amano, Yasuko Ishikawa and Hajie Ishida : Regulation of phosphorylation of Gi2αprotein controls the secretory response to isoproterenol in rat parotid tissues., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1313, No.2, 146-156, 1996.
欧文冊子 ● Ichiro Amano, Yasuko Ishikawa and Hajie Ishida : Regulation of phosphorylation of Gi2αprotein controls the secretory response to isoproterenol in rat parotid tissues., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1313, No.2, 146-156, 1996.

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