『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Takahashi, Mariko (日) (読)
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2. (英) Mimura, Yasuo (日) (読)
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3.林 良夫
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題名 (必須): (英) Role of the ICAM-1/LFA-1 pathway during development of autoimmune dacryoadenitis in an animal model for Sjogren's syndrome  (日)    [継承]
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要約 (任意): (英) We have analyzed the role of cell adhesion molecules during the development of autoimmune dacryodenitis in an NFS/sld mouse model for primary Sjögren's syndrome. The expression of cell adhesion molecules was assessed by RT-PCR and immunohistochemistry. We detected an up-regulation of local cell adhesion molecule genes (ICAM-1, LFA-1, CD44 and Mel-14) in the course of autoimmune lacrimal gland diseases. Immunohistochemically, ICAM-1 was localized exclusively in the endothelial cells of variously sized blood vessels before the onset of disease, and LFA-1, CD44 and Mel-14, expressing infiltrating cells, were found within these lesions. When the therapeutic effects of blocking cell adhesion molecules in vivo were examined, antibodies to ICAM-1 in combination with anti-LFA-1 prevented the development of autoimmune lacrimal gland diseases in NFS/sld mice. These data suggest that in Sjögren's syndrome-like autoimmune dacryoadenitis in NFS/sld mutant mice, the ICAM-1/LFA-1 pathway may play a crucial role in the development and subsequent progression of T-cell-mediated autoimmunity in the lacrimal glands.  (日)    [継承]
キーワード (推奨): 1. (英) Cell adhesion molecules (日) (読) [継承]
2. (英) Autoimmune dacryoadenitis (日) (読) [継承]
3.シェーグレン症候群 (Sjögren's syndrome) [継承]
4. (英) Animal model (日) (読) [継承]
5. (英) NFS/sld mouse (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Pathobiology (S. Karger AG, Basel)
(pISSN: 1015-2008, eISSN: 1423-0291)

ISSN (任意): 1015-2008
ISSN: 1015-2008 (pISSN: 1015-2008, eISSN: 1423-0291)
Title: Pathobiology : journal of immunopathology, molecular and cellular biology
Title(ISO): Pathobiology
Publisher: S. Karger AG
 (NLM Catalog  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 1996年 0月 初日 (平成 8年 0月 初日) [継承]
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DOI (任意): 10.1159/000164058    (→Scopusで検索) [継承]
PMID (任意): 9068010    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Mariko Takahashi, Yasuo Mimura and Yoshio Hayashi : Role of the ICAM-1/LFA-1 pathway during development of autoimmune dacryoadenitis in an animal model for Sjogren's syndrome, Pathobiology, Vol.64, No.5, 269-274, 1996.
欧文冊子 ● Mariko Takahashi, Yasuo Mimura and Yoshio Hayashi : Role of the ICAM-1/LFA-1 pathway during development of autoimmune dacryoadenitis in an animal model for Sjogren's syndrome, Pathobiology, Vol.64, No.5, 269-274, 1996.

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