『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=99815EID:99815, Map:0, LastModified:2016年9月9日(金) 12:01:43, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.歯学部.歯学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kawamata Hitoshi (日) (読)
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2. (英) Nakashiro Koh-ichi (日) (読)
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3.内田 大亮
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4. (英) Hino Satoshi (日) (読)
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5.表原 文江
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6.吉田 秀夫
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7.佐藤 光信
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題名 (必須): (英) Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell  (日)    [継承]
副題 (任意):
要約 (任意): (英) We undertook the present study to clarify the molecular mechanism of the effect of a new anti-cancer drug, vesnarinone, on a human salivary gland cancer cell line, TYS. We isolated TSC-22cDNA as avesnarinone-inducible gene from a cDNA library constructed from vesnarinone-treated TYS cells. TSC-22 was originally reported as a transforming growth factor (TGF)-beta-inducible gene. The expression of TSC-22 was up-regulated within a few hours after treatment with vesnarinone and was continued for 3 days. The level of TSC-22 mRNA in TYS cells was continuously increased until the cells reached confluency. Furthermore, the induction of TSC-22 by vesnarinone was inhibited by treatment with cycloheximide. When we treated the cells with an antisense oligonucleotide against TSC-22 mRNA under quiescent conditions, the antisense oligonucleotide stimulated the growth of TYS cells; however, under growing conditions the antisense oligonucleotide did not affect cell growth. Furthermore, the antisense oligonucleotide suppressed the antiproliferative effect of vesnarinone. These results suggest that TSC-22 may be a negative growth regulator and may play an important role in the antiproliferative effect of vesnarinone.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Agents (日) (読) [継承]
2.細胞周期 (cell cycle) [継承]
3.細胞分裂 (cell division) [継承]
4. (英) Humans (日) (読) [継承]
5. (英) Neoplasm Proteins (日) (読) [継承]
6. (英) Oligonucleotides, Antisense (日) (読) [継承]
7. (英) Quinolines (日) (読) [継承]
8. (英) RNA, Messenger (日) (読) [継承]
9. (英) Repressor Proteins (日) (読) [継承]
10. (英) Salivary Gland Neoplasms (日) (読) [継承]
11. (英) Transcription Factors (日) (読) [継承]
12. (英) Tumor Cells, Cultured (日) (読) [継承]
13. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): British Journal of Cancer (British Empire Cancer Campaign/Cancer Research UK)
(pISSN: 0007-0920, eISSN: 1532-1827)

ISSN (任意): 0007-0920
ISSN: 0007-0920 (pISSN: 0007-0920, eISSN: 1532-1827)
Title: British journal of cancer
Title(ISO): Br. J. Cancer
Publisher: Nature Publishing Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 1998年 0月 初日 (平成 10年 0月 初日) [継承]
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PMID (任意): 9459148    (→Scopusで検索) [継承]
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WOS (任意): 000071502800011 [継承]
Scopus (任意): 2-s2.0-0031974643 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) OtherID: PMC2151252  (日)    [継承]

標準的な表示

和文冊子 ● Hitoshi Kawamata, Koh-ichi Nakashiro, Daisuke Uchida, Satoshi Hino, Fumie Omotehara, Hideo Yoshida and Mitsunobu Sato : Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell, British Journal of Cancer, Vol.77, No.1, 71-78, 1998.
欧文冊子 ● Hitoshi Kawamata, Koh-ichi Nakashiro, Daisuke Uchida, Satoshi Hino, Fumie Omotehara, Hideo Yoshida and Mitsunobu Sato : Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell, British Journal of Cancer, Vol.77, No.1, 71-78, 1998.

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