『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=99734EID:99734, Map:0, LastModified:2018年12月3日(月) 13:18:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.歯学部.歯学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.表原 文江
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2.内田 大亮
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3. (英) Hino Satoshi (日) (読)
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4. (英) Begum NM (日) (読)
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5.吉田 秀夫
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6.佐藤 光信
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7. (英) Kawamata Hitoshi (日) (読)
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題名 (必須): (英) In vivo enhancement of chemosensitivity of human salivary gland cancer cells by overexpression of TGF-beta stimulated clone-22  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have isolated transforming growth factor-beta-stimulated clone-22 (TSC-22) cDNA as an anti-cancer drug-inducible gene in a human salivary gland cancer cell line, TYS. We have previously reported that TSC-22 negatively regulates the growth of TYS cells, and that overexpression of TSC-22 protein in TYS cells enhanced the in vitro chemosensitivity of the cells. In this study, we examined the in vivo chemosensitivity of TSC-22-expressing TYS cells. TSC-22-expressing TYS cells formed tumors in nude mice, but tumors formed by TSC-22-expressing TYS cells were significantly smaller than tumors formed by control cells (p<0.001, one way ANOVA). Furthermore, intraperitoneal injection of 5-fluorouracil (5-FU) markedly inhibited the growth of the TSC-22-expressing TYS tumors, but did not affect the growth of control tumors. It was found by TUNEL assay that TSC-22-expressing TYS tumors were induced to undergo apoptosis by 5-FU treatment. These findings suggest that overexpression of TSC-22 protein in TYS cells enhances the in vivo chemosensitivity of the cells to 5-FU via induction of apoptosis.  (日)    [継承]
キーワード (推奨): 1. (英) Analysis of Variance (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antineoplastic Agents (日) (読) [継承]
4. (英) Apoptosis (日) (読) [継承]
5. (英) Cell Survival (日) (読) [継承]
6. (英) Clone Cells (日) (読) [継承]
7. (英) Fluorouracil (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Nude (日) (読) [継承]
11. (英) Recombinant Fusion Proteins (日) (読) [継承]
12. (英) Recombinant Proteins (日) (読) [継承]
13. (英) Repressor Proteins (日) (読) [継承]
14. (英) Salivary Gland Neoplasms (日) (読) [継承]
15. (英) Transfection (日) (読) [継承]
16. (英) Transplantation, Heterologous (日) (読) [継承]
17. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oncology Reports (Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)

ISSN (任意): 1021-335X
ISSN: 1021-335X (pISSN: 1021-335X, eISSN: 1791-2431)
Title: Oncology reports
Title(ISO): Oncol. Rep.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 737 740 [継承]
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年月日 (必須): 西暦 2000年 7月 初日 (平成 12年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.3892/or.7.4.737    (→Scopusで検索) [継承]
PMID (任意): 10854535    (→Scopusで検索) [継承]
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WOS (任意): 000087545600007 [継承]
Scopus (任意): 2-s2.0-0034219441 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) MedlineDate: 2000 Jul-Aug  (日)    [継承]

標準的な表示

和文冊子 ● Fumie Omotehara, Daisuke Uchida, Satoshi Hino, NM Begum, Hideo Yoshida, Mitsunobu Sato and Hitoshi Kawamata : In vivo enhancement of chemosensitivity of human salivary gland cancer cells by overexpression of TGF-beta stimulated clone-22, Oncology Reports, Vol.7, No.4, 737-740, 2000.
欧文冊子 ● Fumie Omotehara, Daisuke Uchida, Satoshi Hino, NM Begum, Hideo Yoshida, Mitsunobu Sato and Hitoshi Kawamata : In vivo enhancement of chemosensitivity of human salivary gland cancer cells by overexpression of TGF-beta stimulated clone-22, Oncology Reports, Vol.7, No.4, 737-740, 2000.

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