『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.表原 文江
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2. (英) Kawamaha Hitoshi (日) (読)
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[継承]
3.内田 大亮
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4. (英) Hino Satoshi (日) (読)
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5. (英) Nakashiro Koh-ichi (日) (読)
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6. (英) Fujimori Takahiro (日) (読)
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題名 (必須): (英) Vesnarinone, a differentiation-inducing anti-cancer drug, directly activates p21 (waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line  (日)    [継承]
副題 (任意):
要約 (任意): (英) We previously demonstrated that a differentiation inducing drug, vesnarinone induced the growth arrest and p21(waf1) gene expression in a human salivary gland cancer cell line, TYS. In the present study, we investigated the mechanism of the induction of p21(waf1) gene by vesnarinone in TYS cells. We constructed several reporter plasmids containing the p21(waf1) promoter, and attempted to identify vesnarinone-responsive elements in the p21(waf1) promoter. By the luciferase reporter assay, we identified the minimal vesnarinone-responsive element in the p21(waf1) promoter at -124 to -61 relative to the transcription start site. Moreover, we demonstrated by electrophoretic mobility shift assay that Sp1 and Sp3 transcription factors bound to the vesnarinone-responsive element. Furthermore, we found that vesnarinone induced the histone hyperacetylation in TYS cells. These results suggest that vesnarinone directly activates p21(waf1) promoter via the activation of Sp1 and Sp3 transcription factors and the histone hyperacetylation in TYS cells.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Agents (日) (読) [継承]
2.細胞分化 (cell differentiation) [継承]
3. (英) Cyclin-Dependent Kinase Inhibitor p21 (日) (読) [継承]
4. (英) Cyclins (日) (読) [継承]
5. (英) Electrophoretic Mobility Shift Assay (日) (読) [継承]
6. (英) Gene Deletion (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
9. (英) Histone Deacetylases (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Luciferases (日) (読) [継承]
12. (英) Plasmids (日) (読) [継承]
13. (英) Promoter Regions, Genetic (日) (読) [継承]
14. (英) Quinolines (日) (読) [継承]
15. (英) Salivary Gland Neoplasms (日) (読) [継承]
16. (英) Sp1 Transcription Factor (日) (読) [継承]
17. (英) Transcription, Genetic (日) (読) [継承]
18. (英) Transcriptional Activation (日) (読) [継承]
19. (英) Tumor Cells, Cultured (日) (読) [継承]
20. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): British Journal of Cancer (British Empire Cancer Campaign/Cancer Research UK)
(pISSN: 0007-0920, eISSN: 1532-1827)

ISSN (任意): 0007-0920
ISSN: 0007-0920 (pISSN: 0007-0920, eISSN: 1532-1827)
Title: British journal of cancer
Title(ISO): Br. J. Cancer
Publisher: Nature Publishing Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 87 [継承]
(必須): 9 [継承]
(必須): 1042 1046 [継承]
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年月日 (必須): 西暦 2002年 10月 21日 (平成 14年 10月 21日) [継承]
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DOI (任意): 10.1038/sj.bjc.6600592    (→Scopusで検索) [継承]
PMID (任意): 12434298    (→Scopusで検索) [継承]
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WOS (任意): 000179178200020 [継承]
Scopus (任意): 2-s2.0-0037152685 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimo-Tsuga, Tochigi, 321-0293, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC2364327  (日)    [継承]

標準的な表示

和文冊子 ● Fumie Omotehara, Hitoshi Kawamaha, Daisuke Uchida, Satoshi Hino, Koh-ichi Nakashiro and Takahiro Fujimori : Vesnarinone, a differentiation-inducing anti-cancer drug, directly activates p21 (waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line, British Journal of Cancer, Vol.87, No.9, 1042-1046, 2002.
欧文冊子 ● Fumie Omotehara, Hitoshi Kawamaha, Daisuke Uchida, Satoshi Hino, Koh-ichi Nakashiro and Takahiro Fujimori : Vesnarinone, a differentiation-inducing anti-cancer drug, directly activates p21 (waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line, British Journal of Cancer, Vol.87, No.9, 1042-1046, 2002.

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