『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=99727EID:99727, Map:0, LastModified:2016年9月9日(金) 16:21:54, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.歯学部.歯学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.表原 文江
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2. (英) Nakashiro Koh-ichi (日) (読)
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3.内田 大亮
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4. (英) Hino Satoshi (日) (読)
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5. (英) Fujimori Takahiro (日) (読)
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題名 (必須): (英) Transcriptional activation of cyclin-dependent kinasa inhibitor, p21waf1 gene by treatment with a differentiation inducing agent, vesnarinone in a human salivary gland cancer cell line  (日)    [継承]
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要約 (任意): (英) Recently, a new concept for cancer therapy termed "tumor dormancy therapy" has been proposed. The concept of this therapy is to prolong the survival time of cancer patients while maintaining their quality of life. We have been developing a differentiation-inducing therapy, which is included in the tumor dormancy therapy, for salivary gland cancer. In this study, we examined the effect of a differentiation-inducing drug, Vesnarinone on the growth of several cancer cells, and examined the molecular mechanism by which Vesnarinone induces the cyclin dependent kinase inhibitor, p21waf1 in the cancer cells. Vesnarinone significantly suppressed the growth of TYS (salivary gland cancer cells), PC3 (prostate cancer cells), and A431 (squamous cell cancer cells). Furthermore, Vesnarinone dose-dependently enhanced the expression of p21waf1 mRNA in TYS cells. Using the luciferase reporter assay it was found that the enhancement of p21waf1 mRNA expression by Vesnarinone was through direct transcriptional activation of the p21waf1 promoter. Thus, analyzing the molecular mechanisms of differentiation inducing drugs may lead to the development of a new therapeutic strategy for several human malignancies, including salivary gland cancer.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Agents (日) (読) [継承]
2.細胞分化 (cell differentiation) [継承]
3.細胞分裂 (cell division) [継承]
4. (英) Cyclin-Dependent Kinase Inhibitor p21 (日) (読) [継承]
5. (英) Cyclin-Dependent Kinases (日) (読) [継承]
6. (英) Cyclins (日) (読) [継承]
7. (英) Enzyme Inhibitors (日) (読) [継承]
8. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Plasmids (日) (読) [継承]
11. (英) Quinolines (日) (読) [継承]
12. (英) RNA, Messenger (日) (読) [継承]
13. (英) Salivary Gland Neoplasms (日) (読) [継承]
14. (英) Transcriptional Activation (日) (読) [継承]
15. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Experimental & Clinical Cancer Research ([BioMed Central Ltd.])
(pISSN: 0392-9078, eISSN: 1756-9966)

ISSN (任意): 0392-9078
ISSN: 0392-9078 (pISSN: 0392-9078, eISSN: 1756-9966)
Title: Journal of experimental & clinical cancer research : CR
Title(ISO): J. Exp. Clin. Cancer Res.
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2003年 3月 初日 (平成 15年 3月 初日) [継承]
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PMID (任意): 12725323    (→Scopusで検索) [継承]
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WOS (任意): 000182019400008 [継承]
Scopus (任意): 2-s2.0-12244304143 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Dept. of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo-tsuga, Tochigi, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Fumie Omotehara, Koh-ichi Nakashiro, Daisuke Uchida, Satoshi Hino and Takahiro Fujimori : Transcriptional activation of cyclin-dependent kinasa inhibitor, p21waf1 gene by treatment with a differentiation inducing agent, vesnarinone in a human salivary gland cancer cell line, Journal of Experimental & Clinical Cancer Research, Vol.22, No.14, 57-60, 2003.
欧文冊子 ● Fumie Omotehara, Koh-ichi Nakashiro, Daisuke Uchida, Satoshi Hino and Takahiro Fujimori : Transcriptional activation of cyclin-dependent kinasa inhibitor, p21waf1 gene by treatment with a differentiation inducing agent, vesnarinone in a human salivary gland cancer cell line, Journal of Experimental & Clinical Cancer Research, Vol.22, No.14, 57-60, 2003.

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